肖琼，中国医学科学院药物研究所药物化学博士，副研究员。作为药物化学科研骨干参与多项1.1类创新药的研发，主要有免疫抑制类药物艾托莫德与普赛莫德的研发，抗焦虑药布格呋喃的研发及 Keap1-Nrf2 蛋白-蛋白相互作用抑制剂的设计、合成与生物活性评价，曾从事天然产物全合成、小分子手性助剂催化不对称反应的方法学研究及多种杂环合成方法学研究。主持国自然青年基金1项、参与多项国家科技重大专项，国家重点研发计划、国家自然科学基金面上项目等多项。共发表论文37篇，以第一作者或通讯作者发表SCI文章13篇，核心论文4篇。申请专利11项，获授权专利7项。
1. 药物分子设计与合成研究
2. 药物分子合成工艺研究
3. 多种杂环合成方法学研究
4. 基于ABPP技术的药物分子靶标确证研究
1. Xiao Q, Hu M, Chen S, Tang Y, Shi Z, Jin J, Hu J*, Xie P*, Yin D*. Design and synthesis of selective sphingosine-1-phosphate receptor 1 agonists with increased phosphorylation rates. Acta Pharmaceutica Sinica B 2020, 10 (6), 1134-1142. (IF = 11.614)
2. Shi Z, Xiao Q*, Yin D. Synthesis of tetrahydroisoquinolines through TiCl4-mediated cyclization and Et3SiH reduction. Chinese Chemical Letters 2020, 31, 729-732. (IF = 6.779)
3. Shi Z1, Chen S1, Xiao Q*, Yin D. Formation and Disproportionation of Xanthenols to Xanthenes and Xanthones and Its Use in Synthesis. The Journal of Organic Chemistry 2021, 86, 3334-3343. (IF = 4.354, cover paper)
4. Wang H, Hu J, Hu J, Chen Q, Shang N, Liu M, Li X, Xiang L, Yin D, Lan J*, Xiao Q*, Peng Y*. Antidepressant effect of 4-Butyl-alpha-agarofuran via HPA axis and serotonin system. Brain Research Bulletin 2023, 198, 3-14. (IF = 3.715)
5. Xiao Q1, Hu M1, Chen S, Shi Z, Hu J*, Xie P*, Yin D*. Design and synthesis of analogues of the sphingosine-1-phosphate receptor 1 agonist IMMH001 with improved phosphorylation rate in human blood. Bioorganic & Medicinal Chemistry 2020, 28, 115722. (IF = 3.641)
6. Chen S, Shi Z, Xiao Q*, Yin D. Convergent Synthesis of Immune Inhibitor IMMH002. Synthesis 2021, 53 (6), 1174-1180. (IF = 3.157)
7. Xiao Q, Tang Y, Xie P*, Yin D*. Asymmetric amination of α, α-dialkyl substituted aldehydes catalyzed by a simple chiral primary amino acid and its application to the preparation of a S1P1 agonist. RSC Advances 2019, 9, 33497-33505. (IF = 3.119)
8. Xiao Q, Jin J, Wang X., Hu J, Xi M, Tian Y, Yin D*. Synthesis, identification, and biological activity of metabolites of two novel selective S1P1 agonists. Bioorganic & Medicinal Chemistry 2016, 24 (10), 2273-2279. (IF = 2.93)
9. Xiao Q, Hu M, Chen S, Jin J, Li L, Hu J*, Xie P, Yin D*. S1P1-selective agonist prodrug IMMH002 is phosphorylated in rats to form an S-configured enantiomer: Synthesis, verification, and biological activity of the in vivo active metabolite. Bioorganic & Medicinal Chemistry Letters 2020, 30, 127141. (IF = 2.823)
10. Xiao Q, Tang Y, Xie P*. An Efficient Enantioselective Synthesis of (S)-α-methyl-serine Methyl Ester Hydrochloride via Asymmetrically Catalyzed Amination. Journal of Asian Natural Products Research 2020, 22, 61-68. (IF = 1.569)
11. Meng Y1, Xiao Q1, Bai J, Xiao X, Zhang S, Zhu X, Cheng G*, Yin D*. Resolution and chiral recognition of muscone as well as actions on neural system. Journal of Asian Natural Products Research 2014, 16 (12), 1166-1170. (IF = 1.009)
1. 艾托莫德的制备方法。陈思、石泽玉、肖琼、张翔、田育林、尹大力。ZL201811244306，2022-06-21。
2. 一种艾托莫德的制备方法。陈思、石泽玉、肖琼、张翔、田育林、尹大力。ZL201811244290，2022-06-21。
3. 普赛莫德的制备方法。石泽玉、陈思、肖琼、张翔、田育林、尹大力。ZL201811244302，2022-06-21。
4. 一种普赛莫德的制备方法。石泽玉、陈思、肖琼、张翔、田育林、尹大力。ZL201811244291，2022-07-19。
5. 胺基丙二醇类衍生物、其制备方法和其药物组合物与用途。韩伟娟，张海婧，汪小涧，金晶，李刚，张翼，肖琼，周婉琪，陈晓光，尹大力。ZL201280032727，2016-01-20。
6. 含苄氧基苯基的酚类化合物、其制备方法及用途。汪小涧，孙晨斌，葛军，席眉扬，肖琼，尹大力。ZL2016109225616，2021-7-20。
7. 一种2,2-二氟-2,3-二氢取代苯并呋喃类化合物的合成方法。杨旭，张翔，尹大力，肖琼，崔华清，汪小涧，文辉。ZL2017112638549，2021-09-14。
