苑玉和，研究员，博导。 主要研究方向：研究以抗帕金森病为主的创新药物及作用机制。在分子、细胞和动物层面构建多种模型，在此基础上研究以帕金森病发病为主的创新药物。近五年来负责课题共8项，其中国家级项目5项，北京市重点项目1项，面上项目1项。近5年发表SCI收录文章30余篇，申请专利6项。

主要研究方向：研究以帕金森病为主的神经系统疾病创新药物及发病机制。具体研究内容：
1、 基于脑肠轴和神经环路研究帕金森病早期发病机制与防治药物
2、 基于G蛋白偶联受体（GPCRs）研究神经系统疾病治疗药物
3、 利用光遗传技术研究神经系统疾病发病机制
4、 研究防治脊髓损伤的创新药物

1. Han QW, Shao QH, Wang XT, Ma KL, Chen NH, Yuan YH. CB2 receptor activation inhibits the phagocytic function of microglia through activating ERK/AKT-Nurr1 signal pathways. Acta Pharmacol Sin. 2022 Sep;43(9):2253-2266.
2. Bo RX, Li YY, Zhou TT, Chen NH, Yuan YH. The neuroinflammatory role of glucocerebrosidase in Parkinson's disease. Neuropharmacology. 2022 Apr 1;207:108964.
3. Chen Y, Li YY, Wang S, Zhou T, Chen NH, Yuan YH. Ginsenoside Rg1 Plays a Neuroprotective Role in Regulating the Iron-Regulated Proteins and Against Lipid Peroxidation in Oligodendrocytes. Neurochem Res. 2022 Jun;47(6):1721-1735.
4. Heng Y, Li YY, Wen L, Yan JQ, Chen NH, Yuan YH. Gastric Enteric Glial Cells: A New Contributor to the Synucleinopathies in the MPTP-Induced Parkinsonism Mouse. Molecules. 2022 Nov 1;27(21):7414.
5. Li YY, Zhou TT, Zhang Y, Chen NH, Yuan YH. Distribution of α-Synuclein Aggregation in the Peripheral Tissues. Neurochem Res. 2022 Dec;47(12):3627-3634.
6. Liu K, Zhou S, Zhou J, Bo R, Wang X, Xu T, Yuan Y, Xu B. Discovery of 3, 6-disubstituted isobenzofuran-1(3H)-ones as novel inhibitors of monoamine oxidases. Bioorg Med Chem Lett. 2022 Jul 1;67:128748.
7. Wang XT, Sun H, Chen NH, Yuan YH. Tunneling Nanotubes: A Novel Pharmacological Target for Neurodegenerative Diseases? Pharmacol Res. 2021 Mar 9:105541.
8. Zhang CL, Han QW, Chen NH, Yuan YH. Research on developing drugs for Parkinson's disease. Brain Res Bull. 2021 Mar;168:100-109.
9. Shuo Wang, Qi-Wen Han, Tian-Tian Zhou, Cheng-Lu Zhang, Cheng-gen Zhu, Xin Zhou, Nai-Hong Chen, Yu-He Yuan, Jian-Gong Shi, A bibenzyl compound 20C protects rats against 6-OHDA-induced damage by regulating adaptive immunity associated molecules, International Immunopharmacology, Volume 91, 2021, 107269
10. Han QW, Yuan YH, Chen NH. The therapeutic role of cannabinoid receptors and its agonists or antagonists in Parkinson's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2020:109745.
11. Chen Y, Zhang QS, Shao QH, Wang S, Yuan YH, Chen NH, Wang HB. NLRP3 inflammasome pathway is involved in olfactory bulb pathological alteration induced by MPTP. Acta Pharmacol Sin. 2019, 40(8):991-998.
12. Qian-hang Shao, Ying Chen, Fang-fang Li, Shuo Wang, Xiao-ling Zhang, Yu-he Yuan,Nai-hong Chen TLR4 deficiency has a protective effect in the MPTP/probenecid mouse model of Parkinson’s disease Acta Pharmacol Sin. 2019 Acta Pharmacol Sin. 2019，40(12):1503-1512
13. Shao QH, Yan WF, Zhang Z, Ma KL, Peng SY, Cao YL, Yuan YH*, Chen NH*. Nurr1: A vital participant in the TLR4-NF-κB signal pathway stimulated by α-synuclein in BV-2 cells. Neuropharmacology. 2019, 144，388-399 (IF=4.2)
14. Wang S, Yuan YH, Chen NH, Wang HB，The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease. International Immunopharmacology 67 (2019) 458–464
15. Wen L,Zhang QS, Heng Y, Chen Y, Wang S, Yuan YH*, Chen NH*. NLRP3 inflammasome activation in the thymus of MPTP-induced Parkinsonian mouse model. Toxicol Lett. 2018, 5(288):1-8.
16. Shao QH, Zhang XL, Chen Y, Zhu CG, Shi JG, Yuan YH*, Chen NH*. Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways. Mol Immunol. 2018 May 12;99:115-123
17. Chen Y, Shao Q, Yuan YH*, Chen NH*, Prion-like propagation of α-synuclein in the gut-brain axis. Brain Res Bull. 2018，140:341-346.

1. 徐柏玲,苑玉和,周洁,顾朝晴,许彤,李严严,王晓宇,吴伟 ,周诗琦，异苯并呋喃-1(3H)-酮类化合物及其制备方法、药物组合物和用途，2023-05-11，申请号202310527548.0
2. 徐柏玲,苑玉和,周洁,顾朝晴,许彤,李严严,王晓宇,吴伟 ,周诗琦，5,6,7,8-四氢呋喃[3,4-g]异喹啉-3(1H)-酮化合物及其制备方法、药物组合物和用途，2023-05-11，申请号202310527554.6
3. 徐柏玲，苑玉和，刘凯跃，陈乃宏，周洁，李严严，王晓宇，周诗绮，张程璐，薄茹雪，王晓彤,异苯并呋喃-1（3H）-酮类化合物及其制备方法、药物组合物和用途，2022-01-25，申请号：202210085074.4
4. 徐柏玲，苑玉和，刘凯跃，李严严，王晓宇，周诗绮，张程璐，薄茹雪，王晓彤, 苄氧芳基类化合物及其制备方法, 2022-08-26，申请号：202211031912.6
5. 苑玉和，张东明，陈乃宏，李创军，周甜甜，郎光振，韩奇文，魏建和，张程璐，薄茹雪，王晓彤, 7，4′二羟基-8-甲氧基高异黄烷防治帕金森病的应用, 2021-03-15，申请号：202110276474.9
6. 专利名称：天麻中具有神经细胞保护活性的多聚苄类衍生物；申请人：中国医学科学院药物研究所；发明人：石建功，陈乃宏，王亚男，苑玉和，林生，吴苗苗，郭庆兰，朱承根；专利号：ZL 201210159421.X；申请日：2012-05-22，授权 2017-4-26。