刘晓辉，国家海外高层次青年人才。2017年毕业于天津大学药学院，获得博士学位。先后于美国Scripps研究所（2017-2020），哈佛医学院/波士顿儿童医院（2020-2023）从事博士后研究。迄今以第一作者或共同第一作者在Nature，J. Am. Chem. Soc.，Angew. Chem. Int. Ed.，Cell Chem. Biol.等期刊发表论文多篇；获得授权发明专利1项。主持国家自然科学基金面上项目、京津冀基础研究合作专项等多项科技项目。任期刊Pharmaceutical Science Advances青年编委。

1.RNA体内可视化工具的开发及应用；
2.RNA小分子适配体及靶向降解小分子的设计与开发；
3.核酸药物的设计开发与靶向递送。

1. Programming inactive RNA-binding small molecules into bioactive degraders. Yuquan Tong#, Yeongju Lee#, Xiaohui Liu#, Jessica L. Childs-Disney#, Blessy M. Suresh, Raphael I. Benhamou, Chunying Yang, Weimin Li, Matthew G. Costales, Hafeez S. Haniff, Sonja Sievers, Daniel Abegg, Tristan Wegner, Tiffany O. Paulisch, Elizabeth Lekah, Maison Grefe, Gogce Crynen, Montina Van Meter, Tenghui Wang, Quentin M. R. Gibaut, John L. Cleveland, Alexander Adibekian, Frank Glorius*, Herbert Waldmann* and Matthew D. Disney*, Nature, 2023, 618(7963):169-179.
2. Screening of Protonstatin-1 (PS-1) Analogs for Improved Inhibitors of Plant Plasma Membrane H+-ATPase Activity. Yongqing Yang*#, Xiaohui Liu#, Xin Wang#, Wanjia Lv#, Liang Ma#, Xiao Liu#, Haiqi Fu, Shu Song and Xiaoguang Lei*. Front. Plant Sci. 2022, 13:973471.
3. Testing the polar auxin transport model with a selective plasma membrane H+-ATPase inhibitor. Yongqing Yang*#, Xiaohui Liu#, Wei Guo, Wei Liu, Wei Shao, Jun Zhao, Junhong Li, Qing Dong, Liang Ma, Qun He, Yingzhang Li, Jianyong Han, Xiaoguang Lei*. J. Integr. Plant Biol. 2022, 64(6):1229-1245.
4. A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype. Hafeez S Haniff#, Xiaohui Liu#, Yuquan Tong, Samantha M Meyer, Laurent Knerr, Malin Lemurell, Daniel Abegg, Haruo Aikawa, Alexander Adibekian, Matthew D Disney*. Cell Chem. Biol. 2022;29(2):300-311.e10.
5. Reprogramming of protein-targeted small molecule medicines to RNA via ribonuclease targeting chimeras. Peiyuan Zhang#, Xiaohui Liu#, Daniel Abegg, Toru Tanaka, Yuquan Tong, Raphael I Benhamou, Jared Baisden, Gogce Crynen, Samantha M Meyer, Michael D Cameron, Arnab K Chatterjee, Alexander Adibekian, Jessica L Childs-Disney, Matthew D Disney*. J. Am. Chem. Soc. 2021, 143(33), 13044-13055.
6. Targeted Degradation of the Oncogenic MicroRNA 17-92 Cluster by Structure-Targeting Ligands. Xiaohui Liu#, Hafeez S Haniff#, Jessica L Childs-Disney, Anton Shuster, Haruo Aikawa, Alexander Adibekian, Matthew D Disney*. J. Am. Chem. Soc. 2020, 142(15), 6970-6982.
7. Exploring the binding proteins of glycolipids with bifunctional chemical probes. Xiaohui Liu#, Ting Dong#, Yu Zhou, Niu Huang, Xiaoguang Lei*. Angew. Chem. Int. Ed. 2016, 55, 14330-14334.

1. Conversion of a biologically silent miRNA binding small molecule to a miRNA degrader. Matthew Disney, Xiaohui Liu. 2022, WO-2022047148-A1.