科研队伍

1. 工作经历
2018.10-至今 中国医学科学院药物研究所 研究员
2012.10-2018.09 中国医学科学院药物研究所 副研究员
2007.08-2012.09 中国医学科学院药物研究所 助理研究员
2. 教育背景
2002.08-2007.07 北京协和医学院药物研究所 博士
1998.08-2002.07 北京大学医学部 学士

主要研究方向为天然药物活性物质的化学研究:
1、小分子和大分子活性天然产物的发现和功能研究;
2、基于天然药物的创新药物研发。

1. Two new iridoid glucosides from the whole plant of Patrinia scabiosifolia Link. Shikai Sun†, Jiang Fu†, Kaidong Liu, Mingzhu Dai, Yong Li, Yunbao Liu, Shuanggang Ma, Jing Qu*. Molecules, 2021.
2. Humulane-type and germacrane-type sesquiterpenoids from the fruits of Xanthium spinosum Linn. Pengfei Wang, Shuanggang Ma, Li Li, Yuhuan Li, Jing Qu*, Shishan Yu*. Phytochemistry, 2021.
3. Xanthanoltrimer A–C: three xanthanolide sesquiterpene trimers from the fruits of Xanthium italicum Moretti isolated by HPLC-MS-SPE-NMR. Jiang Fu, Ya-Nan Wang, Shuang-Gang Ma, Li Li, Xiao-Jing Wang, Yong Li, Yun-Bao Liu, Jing Qu*, Shi-Shan Yu*. Org. Chem. Front., 2021.
4. Cassane and nor-cassane diterpenoids from the roots of Erythrophleum fordii. Lulu Li, Long Chen, Yuhuan Li, Shikai Sun, Shuanggang Ma, Yong Li, Jing Qu*. Phytochemistry, 2020.
5. Three new alkaloids from Menispermum dauricum. Long Chen, Lu-Lu Li, Yan Cheng, Yun-Bao Liu, Shuang-Gang Ma, Yong Li, Jing Qu*. J. Asian Nat. Prod. Res., 2020.
6. Diterpenoid with diverse carbon skeletons from the roots of Pieris formosa and their analgesic and antifeedant activities. Changshan Niu, Sheng Liu, Yong Li, Yunbao Liu, Shuanggang Ma, Fei Liu, Li Li, Jing Qu*, Shishan Yu*. Bioorg. Chem., 2020.
7. Diverse epoxy grayanane diterpenoids with analgesic activity from the roots of Pieris formosa. Chang-Shan Niu, Yong Li, Yun-Bao Liu, Shuang-Gang Ma, Xiao-Jing Wang, Fei Liu, Sheng Liu, Jing Qu*, Shi-Shan Yu*. Fitoterapia, 2019.
8. Diterpenoid glycosides and monoterpenoid glycosides from the fruits of Xanthium chinense. Yan Cheng, Jiang Fu, Long Chen, Lulu Li, Jing Qu*. J. Asian Nat. Prod. Res., 2019.
9. Grayanane diterpenoids with diverse bioactivities from the roots of Pieris formosa. Chang-Shan Niu, Yong Li, Yun-Bao Liu, Shuang-Gang Ma, Fei Liu, Li Cui, Hai-Bo Yu, Xiao-Jing Wang, Jing Qu*, Shi-Shan Yu*. Tetrahedron, 2018.
10. A novel and practical synthesis of CAT3: a phenanthroindolizidine alkaloid with potential in treating glioblastoma. Rubing Wang, Haining Lv, Shanshan Zhu, Xiaodong Ren, Song Xu, Shuanggang Ma, Yunbao Liu, Jing Qu*, Shishan Yu*. RSC Adv., 2018.
11. Biological and chemical guided isolation of 3,4-secograyanane diterpenoids from the roots of Pieris formosa. Changshan Niu, Yong Li, Yunbao Liu, Shuanggang Ma, Fei Liu, Li Li, Song Xu, Xiaojing Wang, Sheng Liu, Rubing Wang, Jing Qu*, Shishan Yu*. RSC Adv., 2017.
12. Illisimonin A, a caged sesquiterpenoid with a tricyclo[5.2.1.01,6]decane skeleton from the fruits of Illicium simonsii. Shuang-Gang Ma, Mi Li, Ming-Bao Lin, Li Li, Yun-Bao Liu, Jing Qu*, Yong Li, Xiao-Jing Wang, Ru-Bing Wang, Song Xu, Qi Hou, Shi-Shan Yu*. Org. Lett., 2017.
13. Cnidimonins A-C, three types of hybrid dimer from Cnidium monnieri: Structural elucidation and semisynthesis. Fangyi Su, Zheng Zhao, Shuanggang Ma, Rubing Wang, Yong Li, Yunbao Liu, Yuhuan Li, Li Li, Jing Qu*, Shishan Yu*. Org. Lett., 2017.
14. Pierisketolide A and Pierisketones B and C, three diterpenes with an unusual carbon skeleton from the roots of Pieris formosa. Changshan Niu, Yong Li, Yunbao Liu, Shuanggang Ma, Fei Liu, Li Li, Song Xu, Xiaojing Wang, Rubing Wang, Jing Qu*, Shishan Yu*. Org. Lett., 2017.

1. 二聚咖萨因生物碱、其制法和其药物组合物与用途;庾石山,陈晓光,杜丹,屈晶,唐克,徐嵩,马双刚;授权日2014.4.16
2. 一种咖萨因生物碱类似物、其制法和药物组合物与用途;庾石山,陈晓光,徐嵩,屈晶,周晴,马双刚;授权日2014.8.27
3. 间苯三酚类衍生物及其在治疗神经退行性疾病中的用途;庾石山,张丹,王亚丹,鲍秀琦,屈晶,徐嵩,泰文娇,武良玉;授权日2018.7.20
4. 人工熊胆及其制备方法;庾石山,王晓良,李勇,屈晶,马双刚,刘云宝,王玲,徐少峰,冯楠,李江,徐孝先,张和平,郭经;申请号 201610910485.7
5. 一种药物组合物、制备方法及其在缺血性脑卒中治疗中的应用;屈晶,朱海波,普盼盼,渠凯,程妍,杨柳;申请日2018.7.18
6. 三聚苄基异喹啉生物碱、其制法和药物组合物与用途;屈晶,张丹,季鸣,金晶,鲍秀琦,臧彩霞,陈龙,代明珠;申请日2020.2.4

1. 2014年,中草药微量活性物质识别与获取的关键技术及应用;庾石山,石建功,张东明,于德泉,陈晓光,张建军,王珂,申竹芳,马双刚,屈晶;国家科学技术进步奖二等奖
2. 2013年,若干重要中草药中微量活性物质的研究;庾石山,石建功,张东明,于德泉,陈晓光,张建军,王珂,申竹芳,马双刚,林生,徐嵩,李勇,屈晶,吕海宁,李创军;北京市科学技术奖一等奖
3. 2010年,中国若干有毒药用植物活性成分研究;庾石山,陈晓光,再帕尔.阿不力孜,王晓良,屈晶,马双刚;教育部高等学校科技成果奖自然科学一等奖