天然药物活性物质与功能国家重点实验室

个人简介

博士，博士生导师，药物分析专业；中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室研究员，主要研究方向：质谱成像空间分辨代谢组学新技术新方法及其生物医药应用研究。开发出空气动力辅助离子化及质谱成像新技术和空间分辨代谢组学新方法，建立了以空间分辨代谢组学技术为特色的新药代谢研究平台。近5年，发表了包括Nat. Commun., Adv. Sci., PNAS，APSB，JPA，Theranostics，CCL，Anal. Chem.等Q1区论文10余篇。曾获 2010 年北京市科学技术奖二等奖（2）、CAIA 2019 特等奖（2）。国家药品监督管理局创新药物安全与评价重点实验室学委委员；担任《药学学报》、Acta Pharm Sin B、J Pharm Anal青年编委，Molecules、TMR Modern Herbal Medicine和《药学研究》编委；中国医药生物技术协会药物分析技术分会常务委员，中国质谱学会常务委员。

研究方向

1. 质谱成像空间代谢组学新技术及其生物医药应用研究
2. 符合GLP法规的生物样本分析和药物代谢研究
3. 靶向代谢的抗肿瘤新药研发

发表论文

1. Chenglong Sun#, Anqiang Wang#,Yanhe Zhou#, Panpan Chen, Xiangyi Wang, Jianpeng Huang, Jiamin Gao, Xiao Wang, Liebo Shu, Jiawei Lu, Wentao Dai*, Zhaode Bu*, Jiafu Ji* and Jiuming He*. Spatially resolved multi-omics highlights cell-specific metabolic remodeling and interactions in gastric cancer. Nature Communications, 2023，14(1), 2692.（Q1，IF 17.694）
2. Bo Jin, Xuechao Pang, Qingce Zang, Man Ga, Jing Xu, Zhigang Luo, Ruiping Zhang, Jiangong Shi, Jiuming He*, Zeper Abliz*, Spatiotemporally resolved metabolomics and isotope tracing reveal CNS drug targets, Acta Pharmaceutica Sinica B, https://doi.org/10.1016/j.apsb.2022.11.011. (Q1, IF= 14.911)
3. Jianpeng Huang#, Shanshan Gao#, Kai Wang, Jin Zhang, Xuechao Pang, Junwen Shi*, Jiuming He*, Design and characterizing of robust probes for enhanced mass spectrometry imaging and spatially resolved metabolomics, Chinese Chemical Letters, 2023, 34(5): 107865., https://doi.org/10.1016/j.cclet.2022.107865.（Q1，IF 8.455）
4. Xiangyi Wang#, Jin Zhang#, Kailu Zheng, Qianqian Du, Guocai Wang, Jianpeng Huang, Yanhe Zhou, Yan Li*, Hongtao Jin, Jiuming He*. Discovering metabolic vulnerability using spatially resolved metabolomics for antitumor small molecule-drug conjugates development as a precise cancer therapy strategy，Journal of Pharmaceutical Analysis，2023，10.1016/j.jpha.2023.02.010，（Q1， IF 14.0）
5. Xiaowei Song，Qingce Zang，Jin Zhang，Shanshan Gao, Kailu Zheng, Yan Li, Zeper Abliz*, and Jiuming He*，Metabolic Perturbation Score-Based Mass Spectrometry Imaging Spatially Resolves a Functional Metabolic Response，Anal. Chem. 2023, 95, 17, 6775–6784 （Q1， IF 8.08）
6. Dan Liu, Jianpeng Huang, Shanshan Gao, Hongtao Jin, Jiuming He*, A temporo-spatial pharmacometabolomics method to characterize pharmacokinetics and pharmacodynamics in the brain microregions by using ambient mass spectrometry imaging, Acta Pharmaceutica Sinica B, 2022, 12(8), 3341-3353 (Q1, IF= 14.911)
7. Jiuming He#, Chenglong Sun# (共一), Tiegang Li, Zhigang Luo, Luojiao Huang, Xiaowei Song, Xin Li, and Zeper Abliz*, A Sensitive and Wide Coverage Ambient Mass Spectrometry Imaging Method for Functional Metabolites Based Molecular Histology, Advanced Science，2018, 5, 1800250 (Q1, IF= 15.84)
8. Jin Zhang, Qianqian Du, Xiaowei Song, Shanshan Gao, Xuechao Pang, Yan Li, Ruiping Zhang, Zeper Abliz, Jiuming He*, Evaluation of the tumor-targeting efficiency and intratumor heterogeneity of anticancer drugs using quantitative mass spectrometry imaging, Theranostics, 2020; 10(6): 2621-2630 (Q1, IF=11.556)
9. Chenglong Sun, Tiegang Li, Xiaowei Song, Luojiao Huang, Qingce Zang, Jing Xu, Nan Bi, Guanggen Jiao, Yanzeng Hao, Yanhua Chen, Ruiping Zhang, Zhigang Luo, Xin Li, Luhua Wang, Zhonghua Wang, Yongmei Song, Jiuming He* and Zeper Abliz*，Spatially resolved metabolomics to discover tumor-associated metabolic alterations，Proceedings of the National Academy of Sciences of the United States of America，PNAS，2019，116 (1)，52-57 (Q1, IF= 9.412)
10. Xuechao Pang, Shanshan Gao, Man Ga, Jin Zhang, Zhigang Luo, Yanhua Chen, Ruiping Zhang, Jiuming He,* Zeper Abliz*, Mapping metabolic networks in the brain by using ambient mass spectrometry imaging and metabolomics, Anal Chem, 2021，93, 6746−6754 （Q1, IF 6.785）
11. Xiaowei Song#, Jiuming He#, Xuechao Pang, Jin Zhang, Chenglong Sun, Luojiao Huang, Chao Li, Qingce Zang, Xin Li, Zhigang Luo, Ruiping Zhang, Ping Xie, Xiaoyu Liu, Yan Li, Xiaoguang Chen, and Zeper Abliz*，Virtual Calibration Quantitative Mass Spectrometry Imaging for Accurately Mapping Analytes Across Heterogenous Bio-tissue，Anal. Chem., 2019，91, 4, 2838-2846 (Q1, IF=6.785)
12. Xiaowei Song, Zhigang Luo, Xin Li, Tiegang Li, Zhonghua Wang, Chenglong Sun, Luojiao Huang, Ping Xie, Xiaoyu Liu, Jiuming He*, Zeper Abliz*(共同通讯). In situ Hydrogel Conditioning of Tissue Samples to Enhance the Drug’s Sensitivity in Ambient Mass Spectrometry Imaging. Anal Chem, 2017, 89 (12), 6318–6323 (Q1, IF=6.785)
13. Yan Gao, Ruiping Zhang, Jinfa Bai, Xuejun Xia, Yanhua Chen, Zhigang Luo, Jing Xu, Yang Gao, Yuling Liu, Jiuming He*, and Zeper Abliz* "Targeted Data-Independent Acquisition and Mining Strategy for Trace Drug Metabolite Identification Using Liquid Chromatography Coupled with Tandem Mass Spectrometry." Anal chem，2015，87 (15): 7535-7539. （Q1, IF=5.886）
14. Jiuming He, Zeper Abliz,* Ruiping Zhang, Yuxue Liang, and Kuiling Ding，Direct On-Line Method To Monitor the Dynamic Structure of Noncovalent Titanium Complexes in Solution by Using Cold-Spray Ionization Time-of-Flight Mass Spectrometry，Anal. Chem, 2006., 78 (13), 4737 -4740. (Q1, IF 5.635)
15. Zhigang Luo#, Jiuming He#, Yi Chen, Jingjing He, Tao Gong, Fei Tang, Xiaohao Wang, Ruiping Zhang, Lan Huang, Lianfeng Zhang, Haining Lv, Shuanggang Ma, Zhaodi Fu, Xiaoguang Chen, Shishan Yu, and Zeper Abliz*. Air Flow-Assisted Ionization Imaging Mass Spectrometry Method for Easy Whole-Body Molecular Imaging under Ambient Conditions. Anal Chem, 2013, 85(5): 2977-82. (Q1,IF: 5.856)
16. Luojiao Huang, Xinxin Mao, Chenglong Sun, Zhigang Luo, Xiaowei Song, Xin Li, Ruiping Zhang, Yiwei Lv, Jie Chen, Jiuming He*, Zeper Abliz, A graphical data processing pipeline for mass spectrometry imaging-based spatially resolved metabolomics on tumor heterogeneity. Analytica chimica acta, 2019. 1077, 183-190 (Q1，IF=5.977)
17. Lv Yiwei, Li Tiegang, Guo Chengan, Sun Chenglong, Tang Fei, Huang Luojiao, Luo Zhigang, Li Xin, Zhang Ruiping, Zang Qingce, He Jiuming*, Zeper Abliz, A high-performance bio-tissue imaging method using air flow-assisted desorption electrospray ionization coupled with a high-resolution mass spectrometer, Chinese Chemical Letters, 2019, 30, 461–464 (Q2，IF= 4.632)
18. Jiuming He#, Luojiao Huang#（共同第一作者）, Runtao Tian , Tiegang Li , Chenglong Sun ,Xiaowei Song , Yiwei Lv , Zhigang Luo , Xin Li , Zeper Abliz *，MassImager: A software for interactive and in-depth analysis of mass spectrometry imaging data，Analytica Chimica Acta，2018，1015，50-57（Q2, IF=5.977）

专著

专利

科技奖励

1. 再帕尔·阿不力孜，贺玖明，张瑞萍，石建功，乔晋萍，阿布拉江·克依木，项赟，庾石山，耿平，李斌，梁峰，代冬梅，郭娜，常雁，刘永臻，功能分子结构及药物复杂体系多组分的质谱分析新方法，2010年北京市科学技术奖，二等奖。
2．再帕尔·阿不力孜，贺玖明，张瑞萍，石建功，乔晋萍，阿布拉江·克依木，项赟，庾石山，耿平，李斌，梁峰，代冬梅，郭娜，常雁，刘永臻，功能分子结构及药物复杂体系多组分的质谱分析新方法，2011年中华医学科技奖，三等奖。
3．贺玖明，动物体内药物质谱成像分析新技术与新方法研究， 2013第十一届全国医药卫生青年科技论坛一等奖。
4．贺玖明，2015年、2018年度药物研究所“科研岗位标兵”。
5．空气动力辅助离子化质谱成像装置（AFAI-MSI 1000），第十七届中国国际科学仪器及实验室装备展（CISILE2019），自主创新金奖，组织单位：中国仪器仪表行业协会。
6．贺玖明，质谱成像新技术与靶向抗肿瘤新药研发，2019第14届全国医药卫生青年科技论坛一等奖，国家卫生健康委员会科教司。
7. 再帕尔·阿不力孜，贺玖明，孙成龙，罗志刚，宋肖炜，李铁钢，何菁菁，黄罗娇，陈杰，毛歆歆，敞开式质谱分子成像新技术与应用，2019年中国分析测试协会科学技术奖（CAIA 奖）特等奖。