科研队伍

2010-2014,瑞典卡罗林斯卡医学院,药理学系,博士
2015-2017,瑞典乌普萨拉大学,BMC,博士后
作为负责人主持完成课题资助金额共计120余万;参与“科技部重大新药创制”、“医科院创新工程重大协同创新项目”等多项重大课题。2018年借调至国家科技评估中心,作为评估员参与了“重大新药创制”专项的十三五中期评估工作。发表科研论文数十篇,其中第一作者13篇、通讯作者8篇;申报专利9项,已获授权4项(包括国际专利1项)。

1.基于天然产物的创新药研究
2.慢性疼痛及毒品成瘾的新机制及创新疗法研究

1.Kong L#, Rong X#*, Yan P, Qin T, Zhang X, Kang Y, Cheng B, Su W, Gao T, Tie C*. The influence of Hyssopus cuspidatus Boriss extract on lipid mediators metabolism network in asthmatic mice. Front. Pharmacol. 2023; 14:1066643. doi: 10.3389/fphar.2023.1066643.
2.Guo H#, Shen H#, Tang M, Sheng N, Ding X, Lin Y, Zhang J, Jiang J-D, Gao T*, Wang L*, Han Y*. Microbiota-derived short-chain fatty acids mediate the effects of dengzhan shengmai in ameliorating cerebral ischemia via the gut-brain axis. J Ethnopharmacol. 2023; 306:116158. doi: 10.1016/j.jep.2023.116158.
3.Jiang W#, Tang M#, Yang L#, Zhao X#, Gao J#, Jiao Y, Li T, Tie C, Gao T*, Han Y*, Jiang JD*. Analgesic Alkaloids Derived From Traditional Chinese Medicine in Pain Management. Front Pharmacol. 2022;13:851508. doi: 10.3389/fphar.2022.851508.
4.Wang Y, Tong Q, Ma SR, Zhao ZX, Pan LB, Cong L, Han P, Peng R, Yu H, Lin Y, Gao T, Shou JW, Li XY, Zhang XF, Zhang ZW, Fu J, Wen BY, Yu JB, Cao X, Jiang JD. Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota. Signal Transduct Target Ther. 2021; 6(1):77. doi: 10.1038/s41392-020-00456-5. PMID: 33623004.
5.Gao T#, Li T#, Jiang W#, Fan W#, Xu X-J, Zhao X, Yin Z, Guo H, Wang L, Gao J*, Han Y*, Jiang J-D* and Wang D*. Antinociceptive Effects of Sinomenine Combined With Ligustrazine or Paracetamol in Animal Models of Incisional and Inflammatory Pain. Front. Physiol. 2021; 11:523769. doi: 10.3389/fphys.2020.523769.
6.Dondalska A, Rönnberg E, Ma H, Pålsson SA, Magnusdottir E, Gao T, Adam L, Lerner EA, Nilsson G, Lagerström M, Spetz AL. Amelioration of Compound 48/80-Mediated Itch and LL-37-Induced Inflammation by a Single-Stranded Oligonucleotide. Front Immunol. 2020; 11:559589. doi: 10.3389/fimmu.2020.559589.
7.李涛,赵小亮,高天乐,焦玥,高文雅,刘洋,张美玉,王志国,王丹巧*。大鼠血液和脑组织液中游离型青藤碱、川芎嗪、加巴喷丁、扑热息痛、普瑞巴林和阿米替林的微透析液取样及HPLC-MS/MS定量方法研究。药学学报 2020;5(9): 2198-2206.
8.Jiang W#, Fan W#, Gao T#, Li T#, Yin Z, Guo H, Wang L, Han Y*, Jiang J-D. Analgesic Mechanism of Sinomenine against Chronic Pain. Pain Research and Management 2020; 2020:1876862.
9.Ma H#, Gao T#, Jakobsson JET, Weman HM, Xu B, Larhammar D, Lagerström MC*.The Neuropeptide Y Y2 Receptor Is Coexpressed with Nppb in Primary Afferent Neurons and Y2 Activation Reduces Histaminergic and IL-31-Induced Itch. J Pharmacol Exp Ther. 2020; 372(1):73-82. DOI:10.1124/jpet.119.262584.
10.Gao T*, Jiao Y, Liu Y, Li T, Wang Z, Wang D*. Protective Effects of Konjac and Inulin Extracts on Type 1 and Type 2 Diabetes. J Diabetes Res. 2019; 2019:3872182. DOI: 10.1155/2019/3872182.
11.Gao T*, Li T, Jiang W, Fan W, Jiang JD. Exploratory study data for determining the adverse effects of sinomenine plus gabapentin or ligustrazine hydrochloride and the pharmacokinetic insights of sinomenine in plasma and CNS tissue. Data Brief. 2019; 27:104633. DOI: 10.1016/j.dib.2019.104633.
12.Gao T#, Shi T#, Wiesenfeld-Hallin Z, Li T, Jiang JD*, Xu XJ. Sinomenine facilitates the efficacy of gabapentin or ligustrazine hydrochloride in animal models of neuropathic pain. Eur J Pharmacol. 2019; 854:101-108. DOI: 10.1016/j.ejphar.2019.03.061.
13.Fernandez-Zafra T, Gao T, Jurczak A,Sandor K, Hore Z, Agalave NM, Su J, Estelius J, Lampa J, Hokfelt T, Wisenfeld-Hallin Z, Xu X, Denk F,Svensson CI*. Exploring the transcriptome of resident spinal microglia after collagen antibody-induced arthritis. Pain 2019; 160(1): 224-36. DOI:10.1097/j.pain.0000000000001394.
14.Gao T#, Ma H#, Xu B, Bergman J, Larhammar D, Lagerstrom MC*. The Neuropeptide Y System Regulates Both Mechanical and Histaminergic Itch. Journal of Investigative Dermatology 2018; 138:2405-11. DOI:10.1016/j.jid.2018.05.008.

1. 发明专利:一种基于青藤碱的用于镇痛的药物组合产品(A)。发 明 人:高同强、徐晓军、郝景霞、高天乐、苏珊•维森非尔德•哈林。专利授权号:ZL201210154087.9, 公开号:CN102813924 A,在中国和国际专利局注册并已经授权(2014-06-18)。
2. 发明专利:Analgesic pharmaceutical composition. 发 明 人:高同强、徐晓军、郝景霞、高天乐、苏珊•维森非尔德•哈林。欧洲专利授权号:EP 2851074 B1,欧洲专利授权号:EP 2851074 A4, 在欧洲专利局注册并已经授权(2017-08-16)。
3. 发明名称:一种基于青藤碱的用于阵痛的药物组合产品(B)。发 明 人:高同强、徐晓军、郝景霞、高天乐、苏珊•维森非尔德•哈林。专利授权号:ZL201410345147.4,公开号:CN102813924 B,在中国专利局注册并已经授权(2017-07-25)。
4. 发明名称:N-棕榈酰-D-鞘磷脂在制备预防和/或治疗神经性疼痛的药物中的应用。发明人:铁偲、高天乐。专利号:ZL202110731942.7,在中国专利局注册并已经授权(2022-02-22)。