1. 工作经历
2015.3-至今 中国医学科学院北京协和医学院药物研究所，课题组长
2014.1-2015.2 Helmholtz Centre for Infection Research（德国亥姆霍兹感染中心） 化学生物学实验室 Junior PI
2010.9-2013.12 Sanofi（赛诺菲制药集团）Visiting scientist
European Molecular Biology Laboratory博士后
PI: Dr. Oliver Plettenburg (Sanofi)
Dr. Carsten Schultz (EMBL)
2009.7-2010.7 日本名古屋大学 分子设计与有机材料实验室 博士后
导师: Prof. Eiji Yashima（八岛荣次 教授）
2004.9-2009.6 中国科学院化学研究所 分子识别与功能院重点实验室 博士研究生 导师: 陈传峰 (研究员)
2. 教育背景
2004.9-2009.6 中国科学院化学研究所 有机化学专业 博士
2000.9-2004.7 北京理工大学 环境工程专业 学士

以化学生物学为基础，运用化学方法和技术手段，探索生物体内的分子事件，从分子水平认识生命现象的本质，探讨疾病机制。以新药研发为主线，主要针对肿瘤、传染性疾病以及关节炎等重大疾病，开展新型疾病诊断试剂及治疗药物研发，为人类健康提供服务。具体研究内容包括：
1. 酶激活型智能分子探针的设计、合成及应用研究
2. 多模式成像研究
3. 以小分子为运载平台，药物靶向传输研究

1. An Activatable Lanthanide Luminescent Probe for Time-Gated Detection of Nitroreductase in Live Bacteria, Benjamin Brennecke, Qinghua Wang, Qingyang Zhang, Hai-Yu Hu*, and Marc Nazare*, Angewandte Chemie International Edition, 2020.
2. A Pseudopaline Fluorescent Probe for the Selective Detection of Pseudomonas aeruginosa, Tianhu Zhao†, Jian Zhang†, Xiaowan Han†, Jun Yang, Xin Wang, Maarten Vercruysse, Hai-Yu Hu*, Xiaoguang Lei*, CCS Chemistry, 2020.
3. Rapid Differentiation Between Bacterial Infections and Cancer Using a Near-infrared Fluorogenic Probe, Ling-Ling Wu, Qinghua Wang, Yali Wang, Na Zhang, Qingyang Zhang, Hai-Yu Hu*, Chemical Science, 2020.
4. Dual-Mode Detection of Bacterial 16S Ribosomal RNA in Tissues, Shengnan Xu†, Qingyang Zhang†, Xiaowan Han, Yali Wang, Xiang Wang, Marc Nazare, Jian-Dong Jiang*, and Hai-Yu Hu*, ACS Sensors, 2020.
5. A single component self-assembled thermally activated delayed fluorescence nanoprobe, Rao Wei†, Leilei Zhang†, Shengnan Xu, Qingyang Zhang, Yongxiu Qi*, Hai-Yu Hu*, Chemical Communications, 2020.
6. Rationally designed organelle-specific thermally activated delayed fluorescence small molecule organic probes for time-resolved biological applications, Qingyang Zhang†, Shengnan Xu†, Meng Li†, Yali Wang, Na Zhang, Yan Guan, Mingxing Chen, Chuan-Feng Chen*, Hai-Yu Hu*, Chemical Communications, 2019.
7. Rapid Synthesis of γ-halide/Pseudohalide-Substituted Cyanine Sensors with Programmed Generation of Singlet Oxygen, Qingyang Zhang†, Shengnan Xu†, Fangfang Lai†, Yali Wang, Na Zhang, Marc Nazare, Hai-Yu Hu*, Organic Letters, 2019.
8. Ratiometric fluorescent probes for selective and sensitive visualization of bacterial microenvironment protease activity, Qinghua Wang†, Xiang Wang, Ying Sun, Xiaoxiao Yang, Leilei Zhang, Qingyang Zhang, Zhi-Qiang Hu, Hai-Yu Hu*, Chemical Communications, 2019.
9. Tetrahydro[5]helicene-based fluorescent probe for rapid and sensitive detection of bisulfite in living cells, Kun-Peng Wang, Yang Lei, Ying Sun, Qingyang Zhang, Shaojin Chen, Qi Zhang, Hai-Yu Hu⁎, , Zhi-Qiang Hu⁎, Sensors and Actuators B: Chemical, 2018
10. Gadolinium-Labeled Aminoglycoside and Its Potential Application as a Bacteria-Targeting Magnetic Resonance Imaging Contrast Agent, Leilei Zhang†, Yun Liu†, Qingyang Zhang, Tiegang Li, Min Yang, Qingqiang Yao, Xilei Xie, Hai-Yu Hu*, Analytical Chemistry, 2018.
11. A novel nitroreductase-enhanced MRI contrast agent and its potential application in bacterial imaging, Yun Liu, Leilei Zhang*, Marc Nazare, Qingqiang Yao*, Hai-Yu Hu*, Acta Pharmaceutica Sinica B, 2018.
12. Real time detection of ESKAPE pathogens by a nitroreductase-triggered fluorescence turn-on probe, Shengnan Xu, Qinghua Wang, Qingyang Zhang, Leilei Zhang, Limin Zuo, Jian-Dong Jiang, Hai-Yu Hu*, Chemical Communications, 2017.
13. Superior Fluorogen-Activating Protein Probes Based on 3 Indole−Malachite Green, Qingyang Zhang†, Qinghua Wang†, Ying Sun, Limin Zuo, Verena Fetz, Hai-Yu Hu*, Organic Letters, 2017.
14. Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications, Qingyang Zhang†, Qinghua Wang†, Shengnan Xu, Limin Zuo, Xuefu You, Hai-Yu Hu*, Chemical Communications, 2017.

1. 一种特异性靶向细胞内脂滴的长荧光寿命纳米探针，中国医学科学院药物研究所，2021-03-15
2. 超敏感荧光探针检验细菌中硝基还原酶及在细菌感染应用，中国医学科学院药物研究所，2019-10-23
3. 一种热激活延迟荧光探针分子、其制备及其在细胞成像中的应用，中国医学科学院药物研究所，2019-3-04
4. 热激活延迟荧光( TADF )纳米探针及其制备方法和在生物成像中的应用，哈尔滨医科大学，2018-11-08

1. 2018年，法国梅里埃医学院-中国医学科学院青年科学家奖
2. 2016年，北京市科技新星