天然药物活性物质与功能国家重点实验室

个人简介

张钊，中国医学科学院药物研究所药理学博士，副研究员，从事神经系统疾患的发病机制及神经保护活性药物研发工作。主持科研项目8项，含国家自然科学基金青年项目1项，面上项目2项，北京市青年人才托举工程项目等。参与多项国家自然科学基金重点项目、省部级重点研发项目等研究工作，并作为唯一合作单位负责人参与国自然联合基金重点项目1项。在Autophagy, J Neuroinflammation, Br J Pharmacol，Cancer Lett, Cell Death Dis, Brain Behav Immun, Acta Pharmacol Sin 等期刊发表研究论文30余篇；申请国家发明专利6项；参编5部药理相关中英文专著。任中国药理学会补益药专业委员会委员，北京药理学会神经精神药理专委会委员，北京药理学会心脑血管专业委员会委员等。参与BJP、Journal of Ethnopharmacology等期刊的审稿工作。

研究方向

1、帕金森病早发及恶化的分子机制及药物研发
2、脑卒中后修复机制及相关药物研究

发表论文

1. CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction. Wang H, Ye J, Peng Y, Ma W, Chen H, Sun H, Feng Z, He W, Li G, Chu S*, Zhang Z*, Chen N*. Autophagy. 2023 Oct 31. doi: 10.1080/15548627.2023.2276639.
2. A small molecule 20C from Gastrodia elata inhibits α-synuclein aggregation and prevents progression of Parkinson's disease. Peng Y, Ye JR, Wang SS, He WB, Feng ZP, Sun HS, Chu SF*, Zhang Z*, Chen NH*. Cell Death Dis. 2023 Sep 6;14(9):594.
3. A breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke. Wen-Yu Ma, Qing-Lin Wu, Sha-Sha Wang, Hong-Yun Wang, Jun-Rui Ye, Hong-Shuo Sun, Zhong-Ping Feng, Wen-Bin He, Shi-Feng Chu*, Zhao Zhang*, Nai-Hong Chen* Journal of neuroinflammation. 2023;20(1):97.
4. A novel small-molecular CCR5 antagonist promotes neural repair after stroke. Wu QL, Cui LY, Ma WY, Wang SS, Zhang Z, Feng ZP, Sun HS, Chu SF*, He WB*, Chen NH*. Acta Pharmacol Sin. 2023 Oct;44(10):1935-1947.
5. Pyk2 inhibition attenuates hypoxic-ischemic brain injury in neonatal mice. Zhu J, Chu SF, Peng Y, Liu DD, Chen C, Jian WX, Sun HS, Feng ZP, Zhang Z*, Chen NH*. Acta Pharmacol Sin. 2022 April;43(4):797–810.
6. Rg1 exerts protective effect in CPZ-induced demyelination mouse model via inhibiting CXCL10-mediated glial response. Dong YX, Chu SF, Wang SS, Tian YJ, He WB, Du YS, Wang ZZ, Yan X, Zhang Z*, Chen NH*. Acta Pharmacol Sin. 2022 Mar;43(3):563-576.
7. Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours. Yu, X; Bai, Y; Han, B; Ju, M; Tang, T; Shen, L; Li, M; Yang, L; Zhang, Z; Hu, G; Chao, J; Zhang, Y; Yao, H, J Extracell Vesicles. 2022 Jan;11(1):e12185.
8. Low corticosterone levels attenuate late life depression and enhance glutamatergic neurotransmission in female rats. Shi-Feng Chu#, Zhao Zhang#, Xin Zhou, Wen-Bin He, Bo Yang, Li-Yuan Cui, Hong-Yuan He, Zhen-Zhen Wang, Nai-Hong Chen*. Acta Pharmacol Sin. 2021;42(6):848-860.
9. PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery. Tang, Y; Liu, J; Wang, Y; Yang, L; Han, B; Zhang, Y; Bai, Y; Shen, L; Li, M; Jiang, T; Ye, Q; Yu, X; Huang, R; Zhang, Z; Xu, Y; Yao, H, Autophagy, 2021, 17(10): 2905-2922
10. CZ-7, a new derivative of Claulansine F, promotes remyelination induced by cuprizone by enhancing myelin debris clearance. Wang SS#, Bi HZ, Chu SF, Dong YX, He WB, Tian YJ, Zang YD, Zhang DM, Zhang Z*, Chen NH*. Brain Res Bull. 2020 Jun;159:67-78.
11. A20 as a novel target for the anti-neuroinflammatory effect of chrysin via inhibition of NF-κB signaling pathway. Zhi-peng Li#, Shi-feng Chu#, Wen-bin He, Zhao Zhang, Jia-qi Liu, Li-yuan Cui, Xu Yan, De-fang Li, Nai-hong Chen*. Brain Behav Immun. 2019;79:228-235.
12. RTP801 is a critical factor in the neurodegeneration process of A53T α-synuclein in a mouse model of Parkinson's disease under chronic restraint stress. Zhao Zhang#, Shi-Feng Chu#, Sha-Sha Wang, Yi-Na Jiang, Yan Gao, Peng-Fei Yang, Qi-Di Ai, Nai-Hong Chen*. Br J Pharmacol. 2018;175(4):590-605.
13. Helioscopianoids A–Q, bioactive jatrophane diterpenoid esters from Euphorbia helioscopia. Mai ZP#, Ni G, Liu YF, Zhang Z, Li L, Chen NH, Yu DQ*. Acta Pharm Sin B. 2018 Sep;8(5):805-817.
14. Upregulating the Expression of Survivin-HBXIP Complex Contributes to the Protective Role of IMM-H004 in Transient Global Cerebral Ischemia/Reperfusion. Shi-Feng Chu#, Zhao Zhang#, Wei Zhang, Mei-Jin Zhang, Yan Gao, Ning Han, Wei Zuo, Hui-Yong Huang, Nai-Hong Chen*. Mol Neurobiol. 2017;54(1):524-540.
15. Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Zhang Z#, Chu SF, Mou Z, Gao Y, Wang ZZ, Wei GN, Chen NH*.Mol Cell Neurosci. 2016 Mar;71:102-13.
16. The oncoprotein HBXIP enhances migration of breast cancer cells through increasing filopodia formation involving MEKK2/ERK1/2/Capn4 signaling. Li Y#, Zhang Z#, Zhou X, Li L, Liu Q, Wang Z, Bai X, Zhao Y, Shi H, Zhang X*, Ye L*. 2014. Cancer Lett. Dec 28;355 (2):288-96.
17. Tyrosine 402 phosphorylation of Pyk2 is involved in ionomycin-induced neurotransmitter release. Zhang, Z#, Zhang, Y., Mou, Z., Chu, S., Chen, X., He, W., Guo, X., Yuan, Y., Takahashi, M. (*), Chen, N. (*), 2014. PLoS One 9, e94574.

专著

1. 神经生物学（第二版），编者，北京大学出版社，2022。
2. 药理学实验操作教程（全视频展示），编委，中国协和医科大学出版社，2021。
3. 认知科学与认知药理学，编者，化学工业出版社，2020。
4. Natural small molecule drugs from plants, 编者，spring press, 2019。
5. 天然小分子药物-源自植物的小分子药物，编者，人民卫生出版社，2018。

专利

1. 一种以缝隙连接功能为靶标的药物筛选方法，陈乃宏，叶君锐, 楚世峰，张钊，王真真，闫旭，申请号：202211074736.4，2022-9-1。
2. 一种以CKLF1-CCR4相互作用为靶标的药物筛选方法，陈乃宏，楚世峰，叶君锐，张钊，闫旭，申请号：202210701954.X，2022-6-21。
3. 一种以CKLF1-CCR5相互作用为靶标的药物筛选方法，陈乃宏，叶君锐，楚世峰，张钊，闫旭，申请号：202210096374.2，2022-1-26。
4. 一种CCR5抑制剂及其应用，陈乃宏，张钊，楚世峰，崔丽媛，王洪蕴，叶君锐，王真真，闫旭，申请号：202111174028.3，2021-10-9。
5. 一种化合物在制备预防或治疗缺血性脑中风药物中的应用，陈乃宏，张钊，楚世峰，崔丽媛，闫旭，申请号：202110838869.3，2021-7-24。
6. CCR5过表达的人源细胞株的建立及应用，陈乃宏，崔丽媛，楚世峰，张钊，闫旭，申请号：202011396951.7，2020-12-03。

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