訾佳辰，博士，研究员，博士生导师。国家级人才支持计划入选者；天然药物活性物质与功能国家重点实验室课题组长。中西医结合学会分子生药学专业委员会常务委员；中国民族医药学会信息与大数据分会常务理事；北京药学会天然药物专业委员会委员；国家药监局中药质量研究与评价重点实验室学术委员会委员；广东省药品和食品智能制造委员会委员。兼任《Chinese Chemical Letters》、《Chinese Journal of Natural Medicines》等期刊的青年编委。迄今在J. Am. Chem. Soc.，Annu. Rev. Plant Biol.，Angew. Chem. Int. Ed，Proc. Natl. Acad. Sci.，ACS Catal.等期刊发表论文60余篇。
植物活性化合物的异源生物合成研究
1. 植物活性化合物的生源途径研究：利用合成生物学技术体系，结合多组学、计算化学、结构生物学等技术，阐明植物活性成分的生物合成机制。
2. 建立植物活性成分的高效细胞工厂：运用代谢工程和酶工程技术，在微生物底盘细胞中重建植物活性成分的生物合成途径，构建其高效细胞工厂。
3. 基于合成生物学和组学技术的活性化合物发现：利用组学技术从植物中挖掘生物合成基因，通过在底盘菌株表达，量产目标产物，进行活性筛选。
1. Rationally engineering santalene synthase to readjust the component ratio of sandalwood oil. Wenlong Zha, Fan Zhang, Jiaqi Shao, Xingmei Ma, Jianxun Zhu, Pinghua Sun, Ruibo Wu*., Jiachen Zi*. Nature Communications 2022, 13: 2508.
2. Green production of silybin and isosilybin by merging metabolic engineering approaches and enzymatic catalysis. Jiazeng Yang, Jincai Liang, Lei Shao, Lihong Liu, Ke Gao, Junliang Zhang, Zhenjiao Sun, Wendong Xu, Pengcheng, Lin, Rongmin Yu, Jiachen Zi*. Metabolic Engineering 2020, 59: 44–52.
3. Enzyme Promiscuity versus Fidelity in two Sesquiterpene Cyclases (TEAS versus ATAS). Fan Zhang, Tianyue An, Xiaowen Tang, Jiachen Zi*, Hai-Bin Luo*, and Ruibo Wu*. ACS Catalysis 2020, 10: 1470–1484.
4. Reconstruction of the Biosynthetic Pathway of Santalols under Control of the GAL Regulatory System in Yeast. Wenlong Zha, Tianyue An, Ting Li, Jianxun Zhu, Ke Gao, Zhenjiao Sun, Wendong Xu, Pengcheng Lin, Jiachen Zi*. ACS Synthetic Biology 2020, 9(2): 449–456.
5. Characterization of a Sesquiterpene Synthase Catalyzing Formationof Cedrol and Two Diastereoisomers of Tricho-Acorenol from Euphorbia fischeriana. Jianxun Zhu, Lihong Liu, Maobo Wu, Guiyang Xia, Pengcheng Lin, and Jiachen Zi*. Journal of Natural Products 2021, 84: 1780−1786.
6. Mining of the Catharanthus roseus Genome Leads to Identification of a Biosynthetic Gene Cluster for Fungicidal Sesquiterpenes. Jincai Liang, Tianyue An, Jian-Xun Zhu, Shan Chen, Jian-Hua Zhu, Reuben J. Peters*, Rongmin Yu*, Jiachen Zi*. Journal of Natural Products 2021, 84: 2709−2716.
7. Characterization of guaiene synthases from Stellera chamaejasme L. flowers and their application in de novo production of (-)-rotundone in yeast. Tianyue An, Linsheng Li, Ying Lin, Fanqi Zeng, Pengcheng Lin, Jiachen Zi*. Journal of Agricultural and Food Chemistry 2020, 68(10): 3214–3219.
8. Biotechnological Production of Betulinic Acid and Derivatives and Their Applications. Tianyue An, Wenlong Zha, Jiachen Zi*. Applied Microbiology and Biotechnology 2020, 104(8): 3339–3348.
9. Identification of RoCYP01 (CYP716A155) enables construction of engineered yeast for high-yield production of betulinic acid. Jiajian Huang, Wenlong Zha, Tianyue An, Hua Dong, Ying Huang, Dong Wang, Rongmin Yu, Lixin Duan, Xueli Zhang, Reuben J. Peters*, Zhubo Dai*, Jiachen Zi*. Applied Microbiology and Biotechnology 2019, 103(17): 7029–7039.
10. Limonoids from seeds of Azadirachta indica A. Juss. and their cytotoxic activity. Jian Chen, Xiaona Fan, Jianhua Zhu, Liyan Song, Zhiwei Li, Fei Lin, Rongmin Yu*, Hanhong Xu*, Jiachen Zi*. Acta Pharmaceutica Sinica B 2018, 8(4): 639–644.
11. Jiachen Zi, Yuki Matsuba, Young J. Hong, Alana J. Jackson, Dean J. Tantillo, Eran Pichersky and Reuben J. Peters. Biosynthesis of lycosantalonol, a cis-prenyl derived diterpenoid. Journal of the American Chemical Society. 2014, 136: 16951–16953.
12. Jiachen Zi, Sibongile Mafu, and Reuben J. Peters. To Gibberellins and Beyond! Surveying the Evolution of (Di)terpenoid Metabolism. Annual Review of Plant Biology. 2014, 65: 259–286.
1. 《中药化学》（“十四五”普通高等教育规划教材），编委，科学出版社，2022年。
2. 《Natural Medicinal Chemistry》，编委，暨南大学出版社，2022年。
高产桦木酸的酿酒酵母工程菌及其构建方法与应用。ZL201910271339.8。訾佳辰，黄嘉键，查文龙。
2. 高产雅槛蓝醇型倍半萜的酿酒酵母工程菌及其构建方法与应用。ZL201910628500.2。訾佳辰，安天悦。
3. 高产松柏醇的酿酒酵母工程菌及其构建和应用。ZL202010062695.1。訾佳辰，杨加增。
4. 高产紫杉叶素的酿酒酵母工程菌及其构建和应用。ZL202010062712.1。訾佳辰，杨加增。
