陈晶晶，博士，副研究员。2014年毕业于南京师范大学，微生物学专业，获理学博士学位。同年进入中国医学科学院药物研究所生物合成室工作，主要从事活性天然产物的生物合成与合成生物学研究。作为项目负责人，主持国家自然科学基金青年项目1项，中央级公益性科研院所基本科研业务费1项；作为骨干人员，参与国家自然科学基金面上项目、中国医学科学院医学与健康科技创新工程、国家“十三五”重大新药创制专项等。发表SCI论文20余篇，其中以第一作者身份发表SCI论文9篇；申请专利5项，授权2项；参与编写专著1部。

活性天然产物的生物合成与合成生物学研究
1. 通过基因挖掘和功能表征，解析活性天然产物的未知生物合成途径；
2. 利用蛋白质工程改善酶特性，提高其稳定性或催化效率，应用于天然药物高效酶法合成；
3. 运用合成生物学技术，在微生物底盘细胞中设计和构建活性天然产物的生物合成途径，高效生产活性天然产物，拓展药物来源。

1. Jing-Jing Chen, Xiao Liang, Tian-Jiao Chen, Jin-Ling Yang and Ping Zhu*. Mutation of key residues in β-glycosidase LXYL-P1-2 for improved activity. Catalysts, 2021, 11, 1042.
2. Jing-Jing Chen, Xiao Liang, Fen Wang, Yan-Hua Wen, Tian-Jiao Chen,Wan-Cang Liu, Ting Gong, Jin-Ling Yang, Ping Zhu*. Combinatorial mutation on the β-glycosidase specificto7-β-xylosyltaxanes and increasing the mutated enzyme production by engineering the recombinant yeast. Acta Pharmaceutica Sinica B, 2019, 9(3): 626–638.
3. Jing-Jing Chen, Meng-Yao Han, Ting Gong, Yun-Ming Qiao, Jin-Ling Yang, Ping Zhu*. Epigenetic modification enhances ergot alkaloid production of Claviceps purpurea. Biotechnology Letters, 2019, 41: 1439–1449.
4. Jing-Jing Chen, Xiao Liang, Tian-Jiao Chen, Jin-Ling Yang and Ping Zhu*. Site-directed mutagenesis of a β-glycoside hydrolase from Lentinula edodes. Molecules, 2019, 24, 59.
5. Jing-Jing Chen, Xiao Liang, Hui-Xian Li, Tian-Jiao Chen, Ping Zhu*. Improving the catalytic property of the glycoside hydrolase LXYL-P1–2 by directed evolution. Molecules, 2017, 22(12): 2133.
6. Jing-Jing Chen, Meng-Yao Han, Ting Gong, Jin-Ling Yang and Ping Zhu*. Recent progress in ergot alkaloid research. RSC Advances, 2017, 7, 27384.
7. Jing-Jing Chen, Yang-Yang Yong, Xian Xia, Ze-Liang Wang, You-Xing Liang, Zhao Zhang and Ling Lu*, The excreted polysaccharide of Pleurotus eryngii inhibits the foam-cell formation via down-regulation of CD36. Carbohydrate Polymers, 2014, 112: 16-23.
8. Jing-Jing Chen #, Yang-Yang Yong #, Meichun Xing, Yifan Gu, Zhao Zhang, Shizhu Zhang and Ling Lu*. Characterization of polysaccharides with marked inhibitory effect on lipid accumulation in Pleurotus eryngii. Carbohydrate Polymers, 2013, 97: 604-613
9. Jing-Jing Chen, Dong Mao, Yang-Yang Yong, Jieli Li, Hua Wei and Ling Lu*, Hepatoprotective and hypolipidemic effects of water-soluble polysaccharidic extract of Pleurotus eryngii. Food Chemistry, 2012, 130: 687-694.
10. Chen Zhou, Tianjiao Chen, Andi Gu, Zongfeng Hu, Yan Li, Ting Gong, Jingjing Chen, Jinling Yang*, Ping Zhu*. Combining protein and metabolic engineering to achieve green biosynthesis of 12β-O-Glc-PPD in Saccharomyces cerevisiae. Green Chemistry, 2023, 25(4): 1356-1367.
11. Fenglin Jiang, Chen Zhou, Yan Li, Haidong Deng, Ting Gong, Jingjing Chen, Tianjiao Chen, Jinling Yang*, Ping Zhu*. Metabolic engineering of yeasts for green and sustainable production of bioactive ginsenosides F2 and 3β,20S-Di-O-Glc-DM. Acta Pharmaceutica Sinica B, 2022, 12(7): 3167-3176.
12. Yanhua Wen, Tianjiao Chen, Longyu Jiang, Li Li, Mengbo Guo, Yu Peng, Jingjing Chen, Fei Pei, Jinling Yang, Ruishan Wang, Ting Gong*, Ping Zhu*. Unusual (2R,6R)-bicyclo[3.1.1]heptane ring construction in fungal a-trans-bergamotene biosynthesis. iScience, 2022, 25: 104030.
13. Guolin Zhou, Yong Li, Fei Pei, Ting Gong, Tianjiao Chen, Jingjing Chen, Jinling Yang, Qihan Li*, Shishan Yu*, Ping Zhu*. Chromosome-scale genome assembly of Rhododendron molle provides insights into its evolution and terpenoid biosynthesis. BMC Plant Biology, 2022, 22: 342.
14. Lin Yang#, Tian-Jiao Chen#, Fen Wang, Li Li, Wen-Bo Yu, Yi-Kang Si, Jing-Jing Chen, Wan-Cang Liu, Ping Zhu*, Weimin Gong*. Structures of β-glycosidase LXYL-P1-2 reveals the product binding state of GH3 family and a specific pocket for Taxol recognition. Communications Biology, 2020, 3(1): 22
15. Zong-Feng Hu, An-Di Gu, Lan Liang, Yan Li, Ting Gong, Jing-Jing Chen, Tian-Jiao Chen, Jin-Ling Yang* and Ping Zhu*. Construction and optimization of microbial cell factories for sustainable production of bioactive dammarenediol-II glucosides. Green Chemistry, 2019, 21(12): 3286-3299
16. Huichao Liang, Zongfeng Hu, Tingting Zhang, Ting Gong, Jingjing Chen, Ping Zhu, Yan Li, Jinling Yang*. Production of a bioactive unnatural ginsenoside by metabolically engineered yeasts based on a new UDP-glycosyltransferase from Bacillus subtilis. Metabolic Engineering, 2017, 44: 60-69
17. Bing-Juan Li, Hao Wang, Ting Gong, Jing-Jing Chen, Tian-Jiao Chen, Jin-Ling Yang, Ping Zhu*. Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production. Nature Communications, 2017, 8:15544
18. Wancang Liu, Ting Gong, Qinghua Wang, Xiao Liang, Jingjing Chen, Ping Zhu*, Scaling-up Fermentation of Pichia pastoris to demonstration-scale using new methanol-feeding strategy and increased air pressure instead of pure oxygen supplement. Scientific Reports, 2016, 6:18439

1. 《中国食用药用菌化学》. 陈若芸 主编, 上海科学技术文献出版社, 2016 (第十六章 麦角菌).

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