柏健，博士，副研究员，硕士生导师。主要从事天然药物化学与合成生物学研究。主持国家自然科学基金面上项目、青年项目；作为课题骨干参与“十三五”国家“重大新药创制”科技重大专项、国家自然科学基金面上项目、中国医学科学院医学与健康科技创新工程重大协同创新项目、中央级公益性科研院所基本科研业务费专项资金项目等多项科研项目。在Angew. Chem. Int. Ed., J. Am. Chem. Soc., Acta Pharm. Sin. B, Org. Lett.等国际重要期刊上发表研究论文20余篇。相关研究工作受到国际生物和医学论文评价系统“Faculty of 1000”的推荐与好评，同时被天然产物领域权威综述期刊Nat. Prod. Rep.遴选为年度研究热点报道。2018年获中国医学科学院药物研究所“梁周黄于刘青年科技奖”二等奖。

1.基因组导向的活性天然产物的发现：针对特殊生境微生物（植物内生真菌、海洋来源真菌），在基因组生物信息学分析的基础上，利用多种现代生物学技术激活其中的沉默基因，发现其特殊生境下的活性化合物。
2.活性天然产物的生物合成与结构优化：针对新颖结构或稀有的活性分子，阐明其独特的生物合成机制，发现并累积特殊功能的基因元件，利用合成生物学或组合生物合成技术对其进行高效绿色地异源生物合成与结构优化，为新药创制提供先导化合物。

1. Phomoidrides E–G, three dimeric anhydrides from the fungus Pleosporales sp. give new insight to the biosynthesis of phomoidrides. Lihua Zhang, Yanan Wang, Le Zhang, Bingyu Liu, Chen Zhang, Daojiang Yan, Jian Bai*, Youcai Hu*. Organic Chemistry Frontiers, 2021, 8(21): 5926-5933. (cover paper, IF: 5.281)
2. Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products. Qian Wei#, Jian Bai#, Daojiang Yan, Xiuqi Bao, Wenting Li, Bingyu Liu, Dan Zhang, Xiangbing Qi, Dequan Yu, Youcai Hu*. Acta Pharmaceutica Sinica B, 2021, 11(2): 572-587. (cover paper, IF: 11.413)
3. Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscular leads to diverse diterpenoids. Jian Bai, Rong Mu, Man Dou, Daojiang Yan, Bingyu Liu, Qian Wei, Jun Wan, Yi Tang, Youcai Hu*. Acta Pharmaceutica Sinica B, 2018, 8, 687-697. (IF: 5.808)
4. A cascade of redox reactions generates complexity in the biosynthesis of the protein phosphatase-2 Inhibitor rubratoxin A. Jian Bai#, Daojiang Yan#, Tao Zhang, Yongzhi Guo, Yunbao Liu, Yi Zou, Mancheng Tang, Bingyu Liu, Qiong Wu, Shishan Yu*, Yi Tang*, Youcai Hu*. Angewandte Chemie International Edition, 2017, 56, 4782-4786. (IF: 12.102)
5. Alkaloids isolated from the endophytic fungus Fusarium concentricum. Xi-Lin Zhang, Bing-Guo Lu, Jian Bai#, Ning Li#. Natural Product Research, 2022, DOI: 10.1080/14786419.2022.2154346 (IF: 2.488)
6. Amicoumacins from the marine-derived bacterium Bacillus sp. with the inhibition of NO production. Jian Bai, Dong Liu, Siwang Yu, Peter Proksch, Wenhan Lin*. Tetrahedron Letters, 2014, 55, 6286-6291. (IF: 2.391)
7. Sesquiterpenes from the roots of Illicium dunnianum. Jian Bai, Hui Chen, Zhen-Feng Fang, Shi-Shan Yu*, Wen-Jie Wang, Yang Liu, Shuang-Gang Ma, Yong Li, Jing Qu, Song Xu, Jun-Hong Liu, Fen Zhao, Nan Zhao. Phytochemistry, 2012, 80, 137-147. (IF: 3.05)
8. Antioxidant phenolic glycosides from the roots of Illicium dunnianum. Jian Bai, Zhen-Feng Fang, Hui Chen, Shi-Shan Yu*, Dan Zhang, Huai-Ling Wei, Shuang-Gang Ma, Yong Li, Jing Qu, Song Xu, Jing-Hong Ren, Fen Zhao, Nan Zhao, Jun-Hong Liu. Carbohydrate Research, 2012, 361, 206-211. (IF 2.044)
9. Sesquiterpenes and neolignans from the roots of Illicium dunnianum. Jian Bai, Hui Chen, Zhen-Feng Fang, Shi-Shan Yu*, Shuang-Gang Ma, Yong Li, Jing Qu, Song Xu, Jing-Hong Ren, Hai-Ning Lv, Xia Chen. Journal of Asian Natural Products Research, 2012, 14, 940-949. (IF 0.948)
10. Self-resistance in the biosynthesis of fungal macrolides involving cycles of extracellular oxidative activation and intracellular reductive inactivation. Yalong Zhang, Jian Bai, Le Zhang, Chen Zhang, Bingyu Liu, Youcai Hu*. Angewandte Chemie International Edition, 2021, 60, 6639-6645. (IF: 12.959)
11. Highly oxygenated caryophyllene-type sesquiterpenes from a plant-associated fungus, Pestalotiopsis hainanensis, and their biosynthetic gene cluster. Yalong Zhang, Jian Bai, Daojiang Yan, Bingyu Liu, Le Zhang, Chen Zhang, Minghua Chen, Yanhua Mou, Youcai Hu*. Journal of Natural Products, 2020, 83(11), 3262–3269. (IF: 3.779)
12. Enzymatic Intermolecular Hetero-Diels−Alder Reaction in the Biosynthesis of Tropolonic Sesquiterpenes. Qibin Chen#, Jie Gao#, Cooper Jamieson, Jiawang Liu, Masao Ohashi, Jian Bai, Daojian Yan, Bingyu Liu, Yongsheng Che, Yanan Wang, K. N. Houk*, and Youcai Hu*. Journal of the American Chemical Society, 2019, 141(36), 14052-14056. (IF 14.357)
13. Complexity and diversity generation in the biosynthesis of fumiquinazoline-related peptidyl alkaloids. Daojiang Yan#, Qibin Chen#, Jie Gao#, Jian Bai, Bingyu Liu, Yalong Zhang, Le Zhang, Chen Zhang, Yi Zou, Youcai Hu*. Organic Letters, 2019, 21(5), 1475-1479. (IF: 6.492)
14. Activation of an Unconventional Meroterpenoid Gene Cluster in Neosartorya glabra Leads to the Production of New Berkeleyacetals. Tao Zhang#, Jun Wan#, Zhajun Zhan, Jian Bai, Bingyu Liu, Youcai Hu*. Acta Pharmaceutica Sinica B, 2018, 8(3), 478-487. (IF: 5.808)
15. Diphenyl Ethers from a Marine-Derived Aspergillus sydowii. Ya-Nan Wang#, Yan-Hua Mou#, Yu Dong#, Yan Wu, Bing-Yu Liu, Jian Bai, Dao-Jiang Yan, Le Zhang, Dan-Qing Feng, Yue-Hu Pei*, You-Cai Hu*. Marine Drugs, 2018, 16, 451-461. (IF: 3.772)
#co-first author; *Corresponding author.

1. 2018年，中国医学科学院药物研究所“梁周黄于刘”青年科技奖，二等奖。