科研队伍

潘璇 博士,副研究员,硕士生导师,1987年1月3日出生。本科毕业于浙江大学药学院,博士毕业于北京协和医学院。2014年进入中国医学科学院药物研究所工作,2019年聘任为副研究员,主要从事创新药物研发、天然产物全合成、有机合成方法学等方面的工作。主持或参与科研项目8项,其中主持国家自然青年基金项目1项,中央级公益性科研院所基本科研业务费2项,参与的项目包括国家科技重大专项3项、重点实验室自主课题1项、高等学校博士学科点专项科研基金1项。2020年获得药物所“梁周黄于刘”青年科技三等奖。近年来,发表SCI论文20余篇,申请发明专利9项,授权3项。

1. 创新药物的研究与开发
以具有强生物活性的天然产物为结构先导物,利用全合成手段,设计、合成具有生物活性的结构类似物,以期能够发现具有自主知识产权的创新药物。
2. 生物活性天然产物全合成
致力于建立高效的天然产物全合成方法,解决天然产物来源,为后续结构改造奠定基础。
3. 有机合成方法学研究
开发高效的有机化学合成新方法,包括基于苯炔化学构建药物化学常见骨架、使用有机小分子实现常见有机反应的不对称催化等。

1. Asymmetric total synthesis of griseofamine B and its three stereoisomers, Tao Sheng, Caiyun Ma, Guangyan Zhang, Xuan Pan*, Zhanzhu Liu*, Journal of Natural Products, 2022, 85(4), 1128-1133.
2. The asymmetric total synthesis of (−)-eurothiocin A and its enantiomer, Guangyan Zhang, Xuan Pan, Beibei Yang, Li Li, Zhanzhu Liu*, Journal of Natural Products, 2022, 85(4), 997-1005.
3. Design, synthesis and biological evaluation of exiguamine A analogues as IDO1 inhibitors, Junmin Dong, Xuan Pan, Ying Yang, Guangyan Zhang, Zhiyan Xiao, Zhanzhu Liu*, European Journal of Medicinal Chemistry, 2021, 223, 113631-113645.
4. An improved total synthesis of griseofamine A, Xuan Pan‡, Rui Yu‡, Zhanzhu Liu*,Tetrahedron Letters, 2021, 67, 152894-152895.
5. Synthesis and cytotoxicity of (−)-homorenieramycin G and its derivatives, Yantao Ma, Xuan Pan*, Baohe Guan, Guangyan Zhang, Zhanzhu Liu*, Organic & Biomolecular Chemistry, 2020, 18, 9883-9894.
6. Design, synthesis and cytotoxicity of novel hexacyclic saframycin–ecteinascidin analogs, Xiangran Lu, Xuan Pan, Baohe Guan, Zhanzhu Liu*, Organic & Biomolecular Chemistry, 2020, 18, 237-249.
7. Regioselective bromination of 6-hydroxytetrahydroisoquinolines, Ke Wang, Xuan Pan, Kun Peng, Zhanzhu Liu*, Journal of Heterocyclic Chemistry, 2020, 1-4.
8. Total synthesis and antibacterial activity evaluation of griseofamine A and 16-epi-griseofamine A, Xuan Pan, Zhanzhu Liu*, Organic Letters, 2019, 21(7), 2393-2396.
9. A novel specific peroxisome proliferator-activated receptor γ (PPARγ) modulator YR4-42 ameliorates hyperglycaemia and dyslipidaemia and hepatic steatosis in diet-induced obese mice, Yi Huan‡, Xuan Pan‡, Jun Peng, Chunming Jia, Sujuan Sun, Guoliang Bai, Xing Wang, Tian Zhou, Rongcui Li, Shuainan Liu, Caina Li, Quan Liu, Zhanzhu Liu*, Zhufang Shen*, Diabetes Obesity & Metabolism, 2019, 2553-2563.
10. A concise synthesis of (E)-3-aryl-2,3,4,5-tetrahydro-1H-3-benzazonines by aryne induced [2,3] Stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines, Xuan Pan‡, Yantao Ma‡, Zhanzhu Liu*, Organic & Biomolecular Chemistry, 2018, 16(40), 7393-7399.
11. Synthesis of 3-aryl-3-benzazepines via aryne [1,2] Stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines, Xuan Pan, Zhanzhu Liu*, Organic Chemistry Frontiers, 2018, 5(11), 1798-1810.
12. Synthesis and cytotoxicity of novel imidazo[4,5-d]azepine compounds derived from marine natural product ceratamine A, Xuan Pan‡, Lulu Tao‡, Ming Ji, Xiaoguang Chen, Zhanzhu Liu*, Bioorganic & Medicinal Chemistry Letters, 2018, 28(5), 866-868.
13. Asymmetric synthesis of highly functionalized tyrosine derivatives for the construction of bistetrahydroisoquinoline alkaloids, Enming Du, Xuan Pan, Baohe Guan, Zhanzhu Liu*, Tetrahedron Letters, 2018, 59(31), 3029-3032.
14. Design, synthesis and biological evaluation of a series of novel GPR40 agonists containing nitrogen heterocyclic rings, Zhaozhu Sun, Tian Zhou, Xuan Pan, Ying Yang, Yi Huan, Zhiyan Xiao, Zhufang Shen*, Zhanzhu Liu*, Bioorganic & Medicinal Chemistry Letters, 2018, 28(18), 3050-3056.
15. Synthesis and cytotoxicity of a novel series of saframycin-ecteinascidin analogs containing tetrahydro-β-carbboline moieties, Xiangran Lu, Xuan Pan, Ying Yang, Ming Ji, Xiaoguang Chen, Zhiyan Xiao, Zhanzhu Liu*, European Journal of Medicinal Chemistry, 2017, 135(28), 260-269.
16. Effective synthesis and cytotoxicity of novel microtubule-stabilizing agent ceratamine A analogues, Lulu Tao, Xuan Pan**, Ming Ji, Xiaoguang Chen, Zhanzhu Liu*, Tetrahedron, 2017, 73(15), 2159-2171.
17. Stereoselective total synthesis of (±)-parthenolide and (±)-7-epiparthenolide, Liang Li, Xuan Pan, Baohe Guan, Zhanzhu Liu*, Tetrahedron, 2016, 72, 4346-4354.
18. Synthesis and biological evaluation of novel tetrahydroisoquinoline-C-aryl glucosides as SGLT2 inhibitors for the treatment of type 2 diabetes, Xuan Pan, Yi Huan, Zhufang Shen, Zhanzhu Liu*, European Journal of Medicinal Chemistry, 2016, 114, 89-100.
19. Synthesis of indolo[2,3-a]pyrrolo[3,4-c]carbazoles via the oxidative cyclization of bisindolylmaleimides with Pd(TFA)2/Cu(OAc)2, Xuan Pan, Ke Wang, Baohe Guan, Zhanzhu Liu*, Journal of Heterocyclic Chemistry, 2015, 52, 911-913.
20. Asymmetric total synthesis of three stereoisomers of (-)-renieramycin G and their cytotoxic activities, Enming Du, Wenfang Dong, Baohe Guan, Xuan Pan, Zheng Yan, Li Li, Nan Wang, Zhanzhu Liu*, Tetrahedron, 2015, 71, 4296-4303.
21. The preparation of novel chiral auxiliaries SAMIQ/RAMIQ and their application in the asymmetric Michael addition, Xuan Pan, Zhanzhu Liu*, Tetrahedron, 2014, 70, 4602-4610.

1. 一类吲哚-特特拉姆酸化合物、其制备和医药用途,刘站柱,潘璇,胡海宇,马彩云,于瑞,张广艳,贯宝和,魏娆,王晋阳,申请号:202310247411X,申请日:2023年03月15日。
2. 一类抗肿瘤天然产物ecteinascidins结构类似物的制备和医药用途,刘站柱,陈晓光,鲁向冉,潘璇,季鸣,贯宝和,专利号:ZL201810298367.4,授权公告日:2021年04月13日。
3. 一类四氢异喹啉化合物及其盐的制备和医药用途,刘站柱,申竹芳,于然,贯宝和,彭军,潘璇,刘泉,刘率男,孙素娟,李彩娜,孙兆柱,贾春明,姜茜,王悦,周艳丽,专利号:ZL201611207052.1,授权公告日:2021年04月13日。
4. 一类IDO1抑制剂的制备和用途,刘站柱,潘璇,董俊敏,张广艳,贯宝和,申请号:202110313379.1,申请日:2021年03年24日。
5. 一类含中环四氢咔啉-四氢异喹啉化合物的制备和用途,刘站柱,马艳涛,潘璇,贯宝和,张广艳,于瑞,申请号:202010258549.6,申请日:2020年04年03日。
6. 一类含中环的Renieramycin G衍生物的制备和用途,刘站柱,马艳涛,潘璇,贯宝和,张广艳,于瑞,申请号:202010229704.1,申请日:2020年03年27日。
7. 钠糖共转运体2抑制剂、其制法和其药物组合物与用途,刘站柱,申竹芳,潘璇,环奕,刘泉,王悦,专利号:ZL201410218852.8,授权公告日:2019年07月02日。
8. 一类四氢咔啉-四氢异喹啉化合物的制备和医药用途,刘站柱,陈晓光,鲁向冉,潘璇,季鸣,贯宝和,申请号:201811266399.2,申请日:2019年05月07日。
9. GPR40 受体激动剂、其制法和其药物组合物与用途,刘站柱,申竹芳,孙兆柱,潘璇,周甜,环奕,贯宝和,申请号:201810234530.0,申请日:2018年03月21日。