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贾美荣

时间:2021/6/19 来源: 阅读:2472次


贾美荣

 

 

(一)基本信息及联系方式:

姓名

贾美荣

性别

职称

研究员

学历

博士

联系邮箱

jiameirong@imm.ac.cn

联系电话

177012

71357

 

(二)个人简介

1. 工作经历

2021-至今 中国医学科学院&北京协和医学院药物研究所课题组长

2019  University of California, Davis,博士后

2016-2019  Iowa State University,博士后

 

2. 教育背景

2012-2016   Iowa State University    生物化学  博士 (全奖)

2009-2012   山东大学               药物化学  硕士 (推免)

2005-2009   山东大学               制药工程  学士

 

3. 在研项目 

中国医学科学院高层次引进人才启动经费

中国医学科学院药物研究所 独立课题组长人才启动经费

 

(四)研究方向

药用植物活性天然产物的挖掘、生物合成、结构优化和药理活性研究

1. 基于整合组学的活性天然产物的功能基因元件挖掘和鉴定

2. 结合计算模拟的生物酶催化机制阐明和功能设计改造

    3. 基于多元底盘的天然产物及中间体的高效异源生产和结构优化

4. 活性先导物的发现、酶法合成和药理活性研究

 

(五)科研成果

发表论文

1.      Furanoditerpenoid biosynthesis in the bioenergy crop switchgrass is catalyzed by an alternate metabolic pathway. Muchlinski A#, Jia M#, Tiedge K, Fell J, Pelot K, Chew L, Davisson D, Chen Y, Siegel J, Lovell J, Zerbe P. Preprint, 2021, DOI: 10.1101/2021.03.30.437764.

2.      Switching on a nontraditional enzymatic base–deprotonation by serine in the ent-kaurene synthase from Bradyrhizobium japonicum. Jia M#, Zhang Y#, Siegel JB, Tantillo DJ, Peters RJ. ACS Catal., 2019, 9, 8867.

3.      Changing face: A key residue for the addition of water by sclareol synthase. Jia M, O’Brien TE, Zhang Y, Siegel JB, Tantillo DJ, Peters RJ. ACS Catal., 2018, 8:3133.

4.      Combinatorial biosynthesis and the basis for substrate promiscuity in class I diterpene synthases. Jia M, Mishra S, Tufts S, Jernigan R, Peters RJ. Metab Eng., 2019, 55:44.

5.      Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis. Jia M, Potter KC, Peters RJ. Metab Eng., 2016, 37:24.

6.      Jasmonic acid transport in wound-induced systemic immunity. Jia M. Molecular Plant, 2020, 13:1673. Editor’s highlight.

7.      A pair of residues that interactively affect diterpene synthase product outcome. Jia M, Zhou K, Tufts S, Schulte S, Peters RJ. ACS Chem. Biol., 2017, 12:862.

8.      Extending a single residue switch for abbreviating catalysis in plant ent-kaurene synthases. Jia M, Peters RJ. Frontiers in Plant Science, 2016, 7:1765.

9.      Cis or trans with class II diterpene cyclases. Jia M, Peters RJ. Organic & Biomolecular Chemistry, 2017, 15:3158.

10.   Probing the promiscuity of ent-kaurene oxidases via combinatorial biosynthesis. Mafu S, Jia M, Zi J, Morrone D, Wu Y, Xu M, Hillwig ML, Peters RJ. Proc Natl Acad Sci U S A, 2016, 113:2526.

11.   Premutilin synthase: Ring rearrangement by a Class II diterpene cyclase. Xu M, Jia M, Hong YJ, Yin X, Tantillo DJ, Proteau PJ, Peters RJ. Org Lett., 2018, 20:1200.

12.   Product rearrangement from altering a single residue in the rice syn-copalyl diphosphate synthase. Potter KC, Jia M, Hong YJ, Tantillo DJ, Peters RJ. Org Lett., 2016, 18:1060.

13.   Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis. Tu L, Su P, Zhang Z, Gao L, Wang J, Hu T, Zhou J, Zhang Y, Zhao Y, Liu Y, Song Y, Tong Y, Lu Y, Yang J, Xu C, Jia M, Peters RJ, Huang L, Gao W.  Nat Commun., 2020, 11:971.

14.   The analgesic activity of Bestatin as a potent APN inhibitor. Jia M, Wei T, Xu W. Front Neurosci., 2010, 4:1.

15.   Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine. Jia M, Yang K, Fang H, Xu Y, Sun S, Su L, Xu W. Bioorg Med Chem., 2011, 19:5190.

16.   Overview of the synthesis of optically active 3-amino-2-hydroxy-4-phenylbutyric acids, key intermediates for numerous bioactive compounds. Jia M, Wei T, Yang K, Xu W. Mini-Rev Org Chem., 2011, 8:197.

 

专著

Molecular Pharmacognosy, second edition. 编者,chapters 7 and 9Springer2019.

 

科技奖励:

2019、北京海外人才项目、省级个人奖励

 

 

 

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