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靳洪涛

时间:2021/3/19 来源: 阅读:24138次


靳洪涛

 

靳洪涛 研究员,博士生导师。

北京市科技新星;中国毒理学会理事;中国毒理学会临床毒理专委会常委,副秘书长;北京环境诱变剂学会副秘书长;国家健康科普专家库第一批成员(合理用药与药物安全);NMPA创新药物安全研究与评价重点实验室学术委员会委员;《中国比较医学杂志》副主编;《中国药物警戒》、《癌变、畸变、突变》编委。

 

联系方式

Tel 010-67817730E-mailjinhongtao@imm.ac.cn

 

教育背景

1994.9-1998.7  北京中医药大学 中药学  学士

1998.9-2001.7  北京中医药大学  心血管基础药理学  硕士

2006.9-2010.7  北京中医药大学  中药药理学  博士

 

工作经历

2001.8-至今 中国医学科学院药物研究所 新药安全评价研究中心

2002.4-至今 北京协和建昊医药技术开发有限责任公司 

2011.8-2012.8  新疆药物研究所药理一室(援疆)

 

专业研究领域

药物毒害风险因素(肝肾毒性、过敏)识别与有效控制及转化应用;肺功能损害模型建立及有效防护;药物安全性评价研究。先后承担和参与国家自然基金、重大新药创制专项课题、医科院创新工程、协和青年基金、北京市科委、北京市科协、北京协和医学院教改课题等30余项。

 

发表论文

1.Shuting Wang,Wanfang Li, Jianbo Yang, Zengyan Yang, Cuiping Yang,*Hongtao Jin*.Research Progress of Herbal Medicines on Drug Metabolizing Enzymes: Consideration Based on Toxicology. Current Drug Metabolism. 2112):913 – 927.

2.Hong-Ying Li, Jian-Bo Yang, Wan-Fang Li, Cai-Xia Qiu, Guang Hu, Shu-Ting Wang,Yun-Fei Song, Hui-Yu Gaob, Yue Liu, Qi Wang, Ying Wang, Xian-Long Cheng, Feng Wei,Hong-Tao Jin,* Shuang-Cheng Ma,** In vivo hepatotoxicity screening of different extracts, components, and constituents of Polygoni Multiflori Thunb. in zebrafish (Danio rerio) larvae. Biomedicine & Pharmacotherapy.131 (2020) 1105241-18

3. Hui Li, Qianqian Zhang, Wanfang Li, Hongying Li, Jie Bao, Cuiping Yang,Aiping Wang, Jinfeng Wei, Shizhong Chen, Hongtao Jin*. Role of Nrf2 in the antioxidation and oxidative stress induced developmental toxicity of honokiol in zebrafish.Toxicology and Applied Pharmacology. 373 (2019) 4861.

4.Tiantian Liu, Piaopiao Zhang, Yahao Ling, Guang Hu , Jianjun Gu, Hong Yang ,JinfengWei, Aiping Wang Hongtao Jin*. Protective Effect of Colla corii asini against Lung Injuries Induced by Intratracheal Instillation of Artificial Fine Particles in Rats. Int.J.Mol.Sci. 2019, 20(1): 55.

5.Tian-tian Liu, Xin-miao Guo, Zu-yuan Rong, Xiang-feng Ye, Jin-feng Wei, Aiping Wang, Hong-tao Jin*. Comparative toxicity and toxicokinetic studies of oxiracetam and (S)-oxiracetam in dogs.Xenobiotica 2019, 49(9): 1054-10624.ZHANG Qian-qian, LI Qiang, DONG Lin, LI Wan-fang, LI Chao,WANG Ai-ping, WEI Jin-feng, JIN Hong-tao. Genotoxicity and Embryotoxicity Study of Bicyclol Methyl Ether, Main Impurity in Bicyclol. Chin J Integr Med. 2018: 1-7.

6.Jian-Bo Yang, Wan-Fang Li, Yue Liu, Qi Wang, Xian-Long Cheng, Feng Wei,Ai-Guo Wan, Hong-Tao Jin, Shuang-Cheng Ma. Acute toxicity screening of different extractions, components and constituents of Polygonum multiflorum Thunb. on zebrafish (Danio rerio) embryos in vivo. Biomedicine & Pharmacotherapy. 99 (2018) 205213.

7. Liu H.-Q,Wang Y.-M,Li W.-F,Li C,Jiang Z.-H,Bao J,Wei J.-F,Jin H.-T*,Wang A.-P*.Anti-Psoriasis Effects and Mechanisms of Α-(8-Quinolinoxy) Zinc Phthalocyanine-Mediated Photodynamic Therapy. Cell Physiol Biochem. 2017;44:200–214.

8.Han-Qing Liu,Ying-Ming Wang ,Wan-Fang Li, Chao Li ,Zhi-Huan Jiang ,Jie Bao ,Jin-Feng Wei,Hong-Tao Jin*, Ai-Ping Wang*.Photobleaching characteristics of α-(8-quinolinoxy) zinc phthalocyanine ,a new type of amphipathic complex. Open Chemistry. 2017,15400-411.

9.Zheng H, Wang Z, Liu W, Jin H*, Zhang J*.Toxicokinetics of strychnine and brucine after the oral administration of Biqi capsule to rats by RRLC–MS/MS. Biomedical Chromatography. 2017;e4117.https://doi.org/10.1002/bmc.4117.

10.Li J, Wang X L, Wang A P, Xu, S. F., & Jin, H. T*.Toxicokinetics and toxicity of potassium 2-(1-hydroxypentyl)-benzoate in beagle dogs. Journal of Asian natural products research. 2017, 19(4): 388- 401.

11.Ni Lin,Baofeng Liu, Jie Zhang , Yongpeng Long, Guoming Dong, Hongtao Jin*Baiping Ma*.Acute toxicity, 28-day repeated-dose toxicity and toxicokinetic study of timosaponin BII in rats. Regulatory Toxicology and Pharmacology. 2017,90):244-257

12.Ni Lin, Tiantian Liu, Lin Lin, Sheng Lin, Qingce Zang, Jiuming He, Zeper Abliz, Chao Li, Aiping Wang, Hongtao Jin*.Comparison of in vivo immunomodulatory effects of 5-hydroxymethylfurfural and 5, 5-oxydimethylenebis (2-furfural).Regulatory Toxicology and Pharmacology. 2016 ,81 :500-511.

13.Qianqian Zhang, Xiangfeng Ye, Lingzhi Wang, Bangjie Peng , Yingxue Zhang, Jie Bao a, Wanfang Li, Jinfeng Wei, Aiping Wang, Hongtao Jin,* Shizhong Chen*. Embryo-fetal Development Toxicity of Honokiol Microemulsion Intravenously Administered to Pregnant Rats. Regulatory Toxicology and Pharmacology. 2016741):117-122.

14. Ni Lin, Chao Li, Zhonghua Wang, Jingxuan Zhang, Xiangfeng Ye, Wenjing Gao, Aiping Wang, Hongtao Jin*, Jinfeng Wei*. A safety study of a novel photosensitizer,sinoporphyrin sodium, for photodynamic therapy in Beagle dogs.Photochemical & Photobiological Sciences.  201514(4):815-832.

15. Qianqian Zhang, Jianguo Li, Wei Zhang, Quan An, Jianhua Wen, Aiping Wang, Hongtao Jin*, Shizhong Chen*. Acute and sub-chronic toxicity studies of honokiol microemulsion. Regulatory Toxicology and Pharmacology. 201571 (3)428436.

16.Zhixin Jia, Caisheng Wu, Hongtao Jin*,Jinlan Zhang*.Identification of the chemical components of Saussurea involucrate by high-resolution mass spectrometry and the mass spectral treessimilarity filter technique. Rapid Commun. Mass Spectrom. 2014, 28, 22372251.

 

专著

1.药物毒理学研究进展,中国协和医科大学出版社.2020.共同主编.

2.食品毒理学,中国轻工业出版社.2019.编委.

3. Quality Control and Safety Evaluation of Natural Product. Nova Science Publishers, NY, USA.2016.共同主编.

4.营养组学,中国协和医科大学出版社.2015.编委.

5.小动物毒理学.中国农业大学出版社.2014.共同主译.

6.毒代动力学.电子科技大学出版社.2014.副主编.

 

专利

1.豚鼠局部给药、染毒保定带(实用新型专利)

2.大鼠局部给药、染毒保定带(发明专利)

3.家兔局部给药、染毒保定带(发明专利)

4.小型猪局部给药、染毒保定带(发明专利)

5.犬保定带(实用新型专利)

6.新化合物2-糠醇-(5’→11)-1,3-环戊二烯并[5,4-c]-1H-噌啉及其作为抗氧化剂在食品、化妆品或药品中的应用(发明专利)

7.一种栽培菊苣提取物用于肝保护或治疗剂的用途(发明专利)

8.栽培菊苣提取物及其应用(发明专利)

9.一种从栽培菊苣中提取抗氧化活性物的方法(发明专利)

10. 一种大动物保定操作装置 (实用新型专利)

11. 一种5-羟甲基糠醛二聚体在药品安全性控制中的应用(发明专利)

 

 

 

 

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