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张崇敬

时间:2021/6/19 来源: 阅读:15588次


张崇敬

(一)基本信息及联系方式:

 张崇敬,男,博士,研究员。

 联系电话:63165311

 联系邮箱:zhangchongjing@imm.ac.cn

 

(二)个人简介

2005年本科毕业于山东大学药学院。2008年硕士毕业于北京协和医学院药物研究所。2013年毕业于新加坡国立大学化学系药物化学专业,获得博士学位。同年获得中国优秀自费留学生奖学金。2017年入选国家级高层次人才项目。20174月作为中国医学科学院“高端人才引进计划”首位入选者,到北京协和医学院药物所工作,任课题组长。《药学学报》中英两刊青年编委。

 

(三)研究方向

化学生物学和创新药物发现。

1)利用化学蛋白质组学技术,阐明活性分子的蛋白靶标和作用机制,开展机制指导的先导化合物发现。

2)设计、合成小分子荧光探针,用于先导化合物的发现。

 

(四)科研成果

发表论文:

(1) Chen, L.; Wang, H.; Ji, T.-F.*; Zhang, C.-J.* “Chemoproteomics-based target profiling of sinomenine reveals multiple protein regulators of inflammation”. Chem. Commun., 2021, DOI: 10.1039/d1cc01522b.

(2) Zhao, C.; Liu, T.; Xu, M.; Lin, H.; Zhang, C.-J.* “A fundamental study on the fluorescence-quenching effect of nitro groups in tetraphenylethene AIE dyes with electron-withdrawing groups”. Chin. Chem. Lett. 2021, 32, 1925-1928.

(3) Wei, C.; Zhao, C.; Liu, S.; Zhao, J.; Ye, Z; Wang, H.*; Yu, S.*; Zhang, C.-J.* “Activity-based protein profiling reveals thatsecondary-carbon-centered radicals of synthetic 1,2,4-trioxolanes are predominately responsible for modification of protein targets in malaria parasites”. Chem. Commun., 2019, 55, 9535.

(4)  Lin, H.; Yang, W.-Q; Ye, Z; Zhang, C.-J*. “Identification of Potent Caspase-8 Inhibitors from a Library of Fluorescent Natural Products Screened by an AIEgen-based Light-up Probe.” ChemBioChem, 2019, 20, 1292 – 1296. (Invited paper in the special issue of young ChemBio Talent).

(5) Lin, H.; Yang, H.; Huang, S.; Wang, F.; Wang, D.-M.; Liu, B*.; Tang, Y.-D*.; Zhang, C.-J*., Caspase1 Specific Light-Up Probe with Aggregation-Induced Emission Characteristics for Inhibitor Screening of Coumarin-Originated Natural Products. ACS Appl. Mater. Interfaces. 2018, 10, 12173−12180.

(6) Feng, G.; Liu, J.; Zhang, C.-J*.; Liu, B*. Artemisinin and AIEgen Conjugate for Mitochondria-Targeted and Image-Guided Chemo- and Photodynamic Cancer Cell Ablation. ACS Appl. Mater. Interfaces. 2018, 10, 11546−11553.

(7) Yang, H.#; Wang, F.#; Zheng, J.; Lin, H.; Liu, B*.; Tang, Y.-D*.; Zhang, C.-J*. Super-quenched Molecular Probe Based on Aggregation-Induced Emission and Photoinduced Electron Transfer Mechanisms for Formaldehyde Detection in Human Serum. Chem Asian J. 2018, 13, 1432-1437.

(8) Zhang, C.-J.#; Wang, J.#*; Zhang, J.; Lee, Y. M.; Feng, G.; Lim, T. K.; Shen, H.; Lin, Q.; Liu, B*. Mechanism-Guided Design and Synthesis of Mitochondria-targeting Artemisinin Analogue with Enhanced Anticancer Activity. Angew. Chem. Int. Ed., 2016, 55, 13770-13774.

(9) Zhang, C.-J.; Feng, G.; Xu. S.; Zhu, Z.; Lu. X.; Wu. J.; Liu, B*. Structure-dependent cis/trans Isomerization for TetraphenyletheneDerivatives: Consequences for Aggregation-Induced Emission. Angew. Chem. Int. Ed., 2016, 55, 6192-6196. (Selected as Very Important Paper).

(10) Zhang, C.-J.#; Hu, Q.#; Feng, G.; Zhang, R.; Yuan, Y.; Liu, B*. Image-Guided Combination Chemotherapy and Photodynamic Therapy Using a Mitochondria-Targeted Molecular Probe with Aggregation-Induced Emission Characteristics. Chem. Sci., 2015, 6, 4580-4586.

(11) Wang, J. *#; Zhang, C.-J.#; Chia, W. N.; Loh, C. C. Y.; Li, Z.; Lee, Y. Q.; Lee, Y. M.; He, Y.; Yuan, L.; Liu, M.; Liew, C. X.; Zhang, J.; Lim, T. K.;  Lim, C. K.; Shen, H. M.; Tan, K. S. W. *; Lin, Q. S*. Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat. Commun, 2015, 6, 10111.

(12) Zhang, C.-J.; Tan, C. Y. J.; Ge, J.; Na, Z.; Chen, G. Y. J.; Uttamchandani, M.; Sun, H.; Yao, S. Q*. Preparation of Small-Molecule Microarrays by trans-Cyclooctene Tetrazine Ligation and Their Application in the High-Throughput Screening of Protein–Protein Interaction Inhibitors of Bromodomains. Angew. Chem. Int. Ed., 2013, 52, 14060-14064. (Selected as Hot Paper).

(13) Yuan, Y.#; Zhang, C.-J.#; Kwok, R. T. K.; Xu, S.; Zhang, R.; Wu, J.; Tang, B. Z.; Liu, B*. Light-up Probe for Targeted and Activatable Photodynamic Therapy with Real-time In-situ Reporting of Sensitizer Activation and Therapeutic Responses. Adv. Funct. Mater, 2015, 25, 6586-6595.

(14) Yuan, Y.#; Zhang, C.-J.#; Liu, B*. A Photoactivatable AIE Polymer for Light-Controlled Gene Delivery: Concurrent Endo/Lysosomal Escape and DNA Unpacking. Angew. Chem. Int. Ed., 2015, 54, 11419-11423.

(15) Yuan, Y.#; Zhang, C.-J.#; Gao, M.; Zhang, R.; Tang, B. Z.; Liu, B*. Specific Light-Up Bioprobe with Aggregation-Induced Emission and Activatable Photoactivity for the Targeted and Image-Guided Photodynamic Ablation of Cancer Cells. Angew. Chem. Int. Ed., 2015, 54, 1780-1786.

*corresponding author # equal contribution

 

 

 

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