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王金华

时间:2021/4/20 来源: 阅读:28961次


王金华

 

王金华,博士,研究员,博士生导师,课题组长。 中国医学科学院药物研究所引进人才(2015)。现任中国医学科学院药物研究所国家新药筛选中心副主任,实聘课题组长,中国医学科学院药物研究所、北京协和医学院 “协和学者”特聘教授,中国医学科学院医学与健康科技创新工程协同创新团队首席科学家,赣江创新人才。

 

 

教育背景:

1999.8 2004.6    硕、博连读,博士,北京大学

1991.8 1996.6    学士,首都医科大学

 

研究经历:

2015.3至今       中国医学科学院药物研究所、北京协和医学院研究员、博士生导师

2013.2 2015.3    Assistant professor, faculty. John Wayne Cancer Institute, Los Angeles, CA90404 (美国)

2010.8 2013.1    Medical scientist, John Wayne Cancer Institute, Los Angeles, CA 90404. (美国)

2007.10 2010.7   Research Associate, Department of Molecular Oncology, John Wayne Cancer Institute. Los Angeles, CA 90404. (美国)

2006.7 2007.10   Research Associate, Department of Neuropathology, Case Western Reserve University, Cleveland, Ohio USA. (美国)

2004.6 2006.6    博士后,中国医学科学院、中国协和医科大学药物研究所

1996.8 1999.8    江西省人民医院

 

联系方式:

010-63165313 ; 邮箱:wjh@imm.ac.cn ;微信号:wjh92572

 

研究方向:

主要从事肿瘤的机制研究和抗肿瘤相关药物靶点的确认、药物筛选模型的建立及药物筛选、以及活性化合物的深入评价工作、利用生物信息学和网络药理学研发新药。

 

承担科研项目:

1.    2005 Thirty-Seventh Postdoctoral fund (NO.2005037103)

2.    2014 Award from Associates for Breast and Prostate Cancer Research

3.    2014 Award from Margie and Robert E.Peterson breast cancer program

4.    中国医学科学院药物所引进人才科研基金

5.    国家自然科学基金

6.    北京市自然科学基金

7.    “重大新药创制”国家科技重大专项项目,2013ZX09402203、现代中药创新集群与数字制药技术平台

8.   中国医学科学院医学与健康科技创新工程

9.    “协和学者”特聘教授研究基金

10.   活性与功能国家重点实验室”研究基金

11.   “十三五”重大新药创制

12.   人工智能辅助药物发现与研究

 

论文发表,学术期刊编委及审稿人:

目前发表科研论文90余篇,其中在Journal of Clinical Investigation (JCI)Signal Transduct Target TherJournal of the National Cancer Institute (JNCI) Journal of Clinical Oncology (JCO)PNASCancer researchOncogeneHuman Molecular Genetics Journal of Investigative Dermatology OncotargetMolecular Cancer researchBreast Cancer Research TreatmentAnnual of surgical oncologyCell Biochemistry and Biophysics Clinical Hemorheology and Microcirculation等世界著名期刊发表SCI论文60余篇文章。

现为Acta Pharmaceutica Sinica BOncotargetPharmaceutical BiologyMolecular medicine reportJournal of Breast CancerCancer Investigation Asian Life ScienceOncology letter,中国药理学通报,药学学报,医药导报、中国药学杂志等杂志编委和审稿人。

目前还担任中国药理学会全国代表,中国药理学会表观遗传药理专业委员,中国抗癌协和北京中西医整合肿瘤专业委员会常务委员。

 

 

发表论文:

1.Jinhua Wang*, Ying Qu*, Partha S. Ray et al. Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling. Journal of Clinical Investigation. 2011;121(1):212-225. (The article was elected as highlighted article) (IF: 15.366)

2.Tang Q, Li W, Zheng X, Ren L, Liu J, Li S, Wang J*, Du G*. MELK is an oncogenic kinase essential for metastasis, mitotic progression, and programmed death in lung carcinoma. Signal Transduct Target Ther. 2021 6(1):83-94.IF:13.493

3. Jinhua Wang, Wan Li, Ying Zhao et al. Members of FOX family could be drug targets of cancers. Pharmacol Ther. 2018 Jan;181:183-196. (IF: 11)

4. Xiangjin Zheng, Wan Li, Liwen Ren, Jinyi Liu Jinhua Wang*. The Sphingosine Kinase-1 / Sphingosine-1-Phosphate Axis in Cancer: Potential Target for Anticancer Therapy. Pharmacology & Therapeutics. 2019 Mar;195:85-99. (IF: 10.376).

5. P.S Ray, Jinhua Wang, Ying Qu, et al. Role of FOXC1 in regulation of   basal-like/triple-negative breast cancer. Journal of Clinical Oncology. 2009; 27: 562S (No 15S, Part I of II). (IF: 17.255)

6. Jensen TW, Ray T, Wang Jinhua, Li X et al. Diagnosis of Basal-Like Breast Cancer Using a FOXC1-Based Assay. J Natl Cancer Inst. 2015 Jun 3;107(8). (IF13.584)

7. Min Feng, Yi Bao, Zhimei Li, Jinhua Wang, Dave S.B. Hoon et al. RASAL2 activates RAC1 to promote triple-negative breast cancer progression. J Clin Invest. 2014; 124(12):5291-5304. (IF: 13.261)

8. Iida Y, Ciechanover A, Jinhua Wang, Dave Hoon et al. Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma. Clin Cancer Res. 2017 Aug 15; 23(16):4831-4842. (IF: 9.619)

9. Jinhua Wang*, Partha S. Ray*, Ying Qu* et al. FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer. Cancer Research. 2010; 70(10):1-7. (The pictures in the article were chosen as the cover of magazine) (IF: 8.576)

10. Jinhua Wang, I Kuiatse, AJ Casa, AV Lee, X Cui. JNK, essential for anticancer therapy-induced apoptosis promotes cancer breast progession. Cancer Research. 2009; 69( suppl.):(2).January 15,2009 (IF8.576)

11. Jinhua Wang, Sharon Hunag, Ling Takeshima et al. Acquire resistance to braf-inhibitor by increasing EGFR expression. Journal of Investigative Dermatology. 2015; 135:532-541. (IF: 7.216)

12. Jinhua Wang, Ying Qu, Xiaojiang Cui et al. FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-kB signaling. Oncogene, 2012 Nov 8;31(45):4798-802. (IF: 7.18)

13. Wan Li, Liwen Ren, Xiangjin Zheng, Jinyi Liu, Jinhua Wang*, Tengfei Ji*, Guanhua Du*. 3-O-Acetyl-11-keto-β-boswellic acid ameliorated aberrant metabolic landscape and inhibited autophagy in glioblastoma. Acta Pharmaceutica Sinica B, 2020, 10(2): 301-12. (IF:7.097)

14. Jinyi Liu, Jinhua Wang*, et al. The biology, function, and applications of exosomes in cancer. Acta Pharmaceutica Sinica B ( In press). (IF:7.097)

15. Jinhua Wang, Wei hua, Sharon Huang et al. RASSF8 Regulates Progression of Cutaneous Melanoma through Nuclear Factor-κb. Oncotarget, 2015:6:30165-30177. (IF: 6.63)

16. Jinhua Wang, Hirose H, Du G et al. P-REX1 amplification promotes progression of cutaneous melanoma via the PAK1/P38/MMP-2 pathway. Cancer Lett. 2017 Oct 28;407:66-75. (IF: 6.491)

17. Jinhua Wang, Kelly K. Chong, Yoshitaka Nakamura et al. B7-H3 Associated with Tumor Progression and Epigenetic Regulatory Activity in Cutaneous Melanoma. Journal of Investigative Dermatology. 2013; 133(8):2050-8. (IF: 6.19)

 

18. ShuetTheng Lee, min feng, Jinhua Wang et al. Protein Tyrosine Phosphatase UBASH3B is Overexpressed in Triple-Negative Breast Cancer and Promotes Invasion and Metastasis. Proc Natl Acad Sci U S A. 2013, Jul 2; 110(27):11121-6. (IF: 9.598)

19. JianLi Chen, Han Zhang, XueQin Huang, HongYe Wan, Jie Li, XingXing Fan, Kathy Qian Luo, Jinhua Wang, XiaoMing Zhu1*, Jianfang Wang2*. Antiangiogenesis‑Combined Photothermal Therapy in the Second Near‑Infrared Window at Laser Powers Below the Skin Tolerance Threshold. Nano-Micro Lett. (2019) 11:93(IF: 9.043)

120. Marzese DM, Scolyer RA, Jinhua Wang, Kawas NP et al.. Epigenome-wide DNA Methylation Landscape of Melanoma Progression to Brain Metastasis Reveals Aberrations on Homeobox D Cluster Associated with Prognosis. Human Molecular Genetics, 2013; 23(1): 226-38. (IF: 7.541)

21. KatsuyaOhta, Hiromitsu Hoshino, Jinhua Wang et al. MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A. Oncotarget. 2015:6(5):3211-24. (IF: 6.63)

22. Jinyi LiuXiangjin ZhengXiaocong Pang, Cui Yang, Jinhua Wang*. GD3sa novel drug target of cancer.  Acta Pharmaceutica Sinica B. 2018 Sep;8(5):713-720.IF: 5.808

23. Zheng XJ, Li W, Yi J, Liu JY, Ren LW, Zhu XM, Liu SW, Wang JH, Du GH. EZH2 regulates expression of FOXC1 by mediating H3K27me3 in breast cancers. Acta Pharmacol Sin. 2020 Oct 14. (IF=5.064)

24. Wan Li, Jinyi Liu, Weiqi Fu, Xiangjin Zheng, Liwen Ren, Shiwei Liu, Jinhua Wang*, Tengfei Ji*, Guanhua Du*. 3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase. Journal of Experimental & Clinical Cancer Research. 2018 Jul 3;37(1):132 (IF: 5.646 )  

25. Wan Li, Jie Yi, Xiangjin Zheng, Shiwei Liu, Weiqi Fu, Liwen Ren, Li Li, Dave S. B. Hoon, Jinhua Wang*, Guanhua Du. miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway. Clinical Epigenetics. 2018 May 16;10:64.. (IF: 5.496 )                                 

26. Jie Yu, Jinhua Wang* et al. Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer. Oncotarget. 2017 Mar 28; 8(13):20751-20765. (IF: 5.168)

27. Jinhua Wang et al. Research progress on the Forkhead Box C1. Oncotarget, 2017 Nov 20;9(15):12471-12478.. (IF: 5.168)

28. Yi J, Gao R, Chen Y, Yang Z, Han P, Zhang H, Dou Y, Liu W, Wang W, Du G, Xu Y, Wang J*. Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer. Oncotarget. 2017 Mar 28;8(13):20751-20765. (IF: 5.168)

29. Wang Jinhua, Li Li, Liu Shiwei, Zhao Ying, Wang Lin, Du Guanhua. FOXC1 promotes melanoma by activating MST1R/PI3K/AKT pathway. Oncotarget. 2016 Dec 20; 7(51):84375-84387. (IF: 5.168)

30. Qin Tang, Liwen Ren, Jinyi Liu, Wan Li, Xiangjin Zheng, Jinhua Wang*, Guanhua Du*. Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4ATF3-CHOP axis. Cell Prolif. 2019 Oct 23:e12706. (IF: 5.039)

31. Jin-yi Liu, Wei-qi Fu, Xiang-jin Zheng, Wan Li, Li-wen Ren, Jin-hua Wang*, Cui Yang* and Guan-hua Du*. Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest. Acta Pharmacologica Sinica, 2020. (IF: 5.064)

32. Jinhua Wang, Isere Kuiatse, Adrian V. Lee et al. Sustained JNK Activity Promotes Epithelial-Mesenchymal Transition, Invasion, and Survival of Breast Cancer Cells by Regulating  ERK Activation. (Molecular Cancer Research, 2010; 8(2):266-277). (The article was elected as highlighted article) (IF: 4.937)

33. Jie Yi, Liwen Ren, Dandan Li, Jie Wu, Wan Li, Guanhua Du, Jinhua Wang*. Trefoil factor 1 (TFF1) is a potential prognostic biomarker with functional significance in breast cancers [J]. Biomedicine & Pharmacotherapy, 2020, 124(109827). (IF: 4.545)

34. Jinhua Wang*, Ying Qu*, Bingya Liu, Armando Giuliano et al. Elesclomol, counteracted by Akt survival signaling, enhances the apoptotic effect of chemotherapy drugs in breast cancer cells. (Breast Cancer Research and Treatment, 2010; 121(2):311-21. (IF: 4.467)

国际专利:

Patent 1: METHODS FOR DIAGNOSIS, PROGNOSIS AND TREATMENT OF PRIMARY AND METASTATIC BASAL-LIKE BREAST CANCER AND OTHER CANCER TYPES  Patent No. US 9074253 B2  授权日: 2015.7.7.

Patent 2: DIAGNOSIS OF PRIMARY AND METASTATIC BASAL-LIKE BREAST CANCER AND OTHER CANCER TYPES  Patent No. EP 2486149 B1  授权日: 2015.6.17.

国内专利:

专利1:醉茄素A在制备预防或治疗胶质母细胞瘤药物中的应用。王金华等。申请号:201810266304.0

专利2:乳香酸及其衍生物的制备与其抗神经胶质瘤的用途。王金华等。申请号:201810581480.3

专利 3:阿伐麦布在制备预防或治疗胶质母细胞瘤药物中的应用。王金华等。申请号:201811248470.4

专利 4:载脂蛋白C 1在作为胃癌诊断及预后评价生物标记物中的应用。王金华等。申请号:201910163695.8

专利 5:青藤碱类化合物在制备预防或治疗神经胶质瘤药物中的应用。王金华等。申请号:201910671599.4

专利 6:三个唑类化合物在制备抗神经胶质瘤药物中的应用。王金华等。申请号:202010189295.7

专利 7:黄芩素在制备预防和/或治疗新冠病毒感染疾病的药物中的应用。杜冠华,吕扬….王金华等。申请号:202010133944.1

参编专著:

1.  丹参大全.  ISBN:978-7-117-09935-6/R.9936.  2008, Page: 242-248

2.  人类疾病动物模型. ISBN: 978-7-81116-231-8.   2007, Page: 88-85

3. 《天然小分子药物-源自于植物的小分子药物》副主编 2018

4. 《中药材“毒”之古今研究概评》2018

5.  Nature small molecule drugs from plants 2018

6.  《中国医学科技发展报告》2019

7.  《实验药理学》副主编2021

8.  《漫话糖尿病》2017

9. 《糖尿病生活百科》 2018

 

 

 

 

 

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