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李平平

时间:2021/3/19 来源: 阅读:36218次


李平平

 

李平平,博士,研究员,博士生导师。2015年获得协和学者特聘教授称号; 2016年入选国家自然基金委优秀青年;2017年入选求是杰出青年科学家。2018年入选北京高校“卓越青年”科学家,2020年获得第七届“树兰医学奖”。现任中国医学科学院代谢紊乱和肿瘤发生相关机制和靶点发现重点实验室主任,中国医学科学院北京协和医学院学术委员会委员,中国药学会青年委员会委员,北京市侨联青年委员会委员,北京生理科学会理事,中国医学科学院青年科学家联盟理事,卫生健康青年创新中心第一届青年导师团导师,《药学学报》和《Metabolism Open》 编委。累计发表SCI论文50余篇,引用5000余次。主要研究工作 (通讯作者或第一作者)发表在Cell3篇)、Nature MedicineCell MetabolismPNAS Diabetes 等期刊。

 

联系方式

邮箱:lipp@imm.ac.cn

 

教育背景

2006-2011:博士后,美国加州大学圣迭戈分校,医学院

2001-2006:博士,中国医学科学院北京协和医学院药物研究所, 药理学

1996-2001:学士,中国药科大学,药理学

 

工作经历

2015-至今:研究员,中国医学科学院北京协和医学院药物研究所

2013-2015:助理教授,美国加州大学圣迭戈分校,医学院

2011-2013:项目科学家,美国加州大学圣迭戈分校,医学院

 

专业研究领域

致力于肥胖、胰岛素抵抗及糖尿病发生的分子免疫学机制研究,目前课题组隶属于“天然药物活性物质与功能”国家重点实验室,主要研究领域包括内分泌学和内分泌药理学、免疫生物学和免疫药理、分子细胞生物学和药理学、信号传导通道调节机制等。

 

发表论文

1.    Chifa Ma, Yiwen Liu , Shuli He, Jingbo Zeng , Pingping Li  , Chunxiao Ma, Fan Ping , Huabing Zhang , Lingling Xu, Wei Li , Yuxiu Li. Association Between Leukocyte Mitochondrial DNA Copy Number and Non-alcoholic Fatty Liver Disease in a Chinese Population Is Mediated by 8-Oxo-2'-Deoxyguanosine. Front Med (Lausanne). 2020;7:536.

2.    Chifa Ma, Yiwen Liu , Shuli He , Jingbo Zeng , Pingping Li  , Chunxiao Ma , Fan Ping , Huabing Zhang   , Lingling Xu , Wei Li , Yuxiu Li. Negative association between antioxidant vitamin intake and non-alcoholic fatty liver disease in Chinese non-diabetic adults: mediation models involving superoxide dismutase. Free Radic Res. 2020; 28:1-8.

3.    Ke Li , Feng Wang , Zhao-Na Yang, Bing Cui , Ping-Ping Li , Zhen-Yu Li , Zhuo-Wei Hu , Hong-Hu Zhu. PML-RARα interaction with TRIB3 impedes PPARγ/RXR function and triggers dyslipidemia in acute promyelocytic leukemia. Theranostics. 2020;10(22):10326-10340

4.    Jie Yu, Haibin Liu , Shuli He , Pingping Li , Chunxiao Ma , Minglei Ma , Yiwen Liu , Lu Lv , Fan Ping  , Huabing Zhang , Wei Li , Qi Sun , Lingling Xu , Yuxiu Li. Corrigendum to "Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α". Mediators Inflamm. 2020;2594730.

5.    Minglei Ma, Chifa Ma , Pingping Li , Chunxiao Ma, Fan Ping , Wei Li , Lingling Xu, Huabing Zhang , Qi Sun , Yuxiu Li. Low glucose enhanced metformin's inhibitory effect on pancreatic cancer cells by suppressing glycolysis and inducing energy stress via up-regulation of miR-210-5p. Cell Cycle.2020; 19(17):2168-2181.

6.    Chifa Ma , Shuli He , Pingping Li , Huabing Zhang , Wei Li , Yuxiu Li. Negative Association between Caloric Intake and Estimated Glomerular Filtration Rate in a Chinese Population: Mediation Models Involving Mitochondrial Function. Gerontology. 2020;66(5):439-446.

7.    Yiwen Liu , Chifa Ma, Lu Lv , Pingping Li , Chunxiao Ma , Shuli He, Jingbo Zeng , Fan Ping , Huabing Zhang , Wei Li , Lingling Xu , Yuxiu Li. Relationship between Decreased Serum Superoxide Dismutase Activity and Metabolic Syndrome: Synergistic Mediating Role of Insulin Resistance and β-Cell Dysfunction. Oxid Med Cell Longev. 2020:5384909.

8.    Jie Yu , Haibin Liu , Shuli He , Pingping Li , Chunxiao Ma , Minglei Ma , Yiwen Liu , Lu Lv , Fan Ping, Huabing Zhang , Wei Li , Qi Sun , Lingling Xu , Yuxiu Li. Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α. Mediators Inflamm. 2020:7610436.

9.    Yiwen Liu , Chifa Ma , Pingping Li , Chunxiao Ma, Shuli He , Fan Ping , Huabing Zhang , Wei Li , Lingling Xu , Yuxiu Li. Potential Protective Effect of Dietary Intake of Non- α-Tocopherols on Cellular Aging Markers Mediated by Tumor Necrosis Factor- α in Prediabetes: A Cross-Sectional Study of Chinese Adults. Oxid Med Cell Longev. 2020:7396801.

10. Minglei Ma , Haibin Liu, Jie Yu , Shuli He , Pingping Li , Chunxiao Ma, Huabing Zhang , Lingling Xu  , Fan Ping, Wei Li , Qi Sun , Yuxiu Li. Triglyceride is independently correlated with insulin resistance and islet beta cell function: a study in population with different glucose and lipid metabolism states. Lipids Health Dis.2020: 19(1):121.

11. Yiwen Liu, Chifa Ma , Pingping Li , Chunxiao Ma , Shuli He , Fan Ping  , Huabing Zhang , Wei Li , Lingling Xu , Yuxiu Li. Leukocyte Telomere Length Independently Predicts 3-Year Diabetes Risk in a Longitudinal Study of Chinese Population. Oxid Med Cell Longev. 2020:9256107.

12. Fangfang Sun, Yilie Liao, Xingfan Qu, Xia Xiao, Shaocong Hou, Zheqin Chen, Haipeng Huang, Pingping Li, and Suneng Fu. Hepatic DNAJB9 Drives Anabolic Biasing to Reduce Steatosis and Obesity. Cell Reports 2020; 30: 1835–1847.

13. Liu, S. S., Lv, X. X., Liu, C., Qi, J., Li, Y. X., Wei, X. P., Li, K., Hua, F., Cui, B., Zhang, X. W., Yu, J. J., Yu, J. M., Wang, F., Shang, S., Zhao, C. X., Hou, X. Y., Yao, Z. G., Li, P. P., Li, X., Huang, B., and Hu, Z. W. (2019) Targeting Degradation of the Transcription Factor C/EBPbeta Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages. Immunity 51, 522-534 e527.

14. Zhang, Q., Pan, Y., Zeng, B., Zheng, X., Wang, H., Shen, X., Li, H., Jiang, Q., Zhao, J., Meng, Z. X., Li, P., Chen, Z., Wei, H., and Liu, Z. (2019) Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells. Cell Res 29, 516-532.

15. Yu J, Liu H, He S, Li P, Ma C, Ma M, Liu Y, Lv L, Ping F, Zhang H, Li W, Sun Q, Xu L, Li Y. Sex-Specific Negative Association between Iron Intake and Cellular Aging Markers: Mediation Models Involving TNFα. Oxid Med Cell Longev. 2019 Nov 11;2019:4935237.

16. Yu J, Liu H, He S, Li P, Ma C, Ping F, Zhang H, Li W, Sun Q, Ma M, Liu Y, Lv L, Xu L, Li Y. Negative Association of Serum URIC Acid with Peripheral Blood Cellular Aging Markers. J Nutr Health Aging. 2019;23(6):547-551.

17. Yu JM, Sun W, Wang ZH, Liang X, Hua F, Li K, Lv XX, Zhang XW, Liu YY, Yu JJ, Liu SS, Shang S, Wang F, Yang ZN, Zhao CX, Hou XY, Li PP, Huang B, Cui B, Hu ZW. TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription. Nat Commun. 2019 Dec 16;10(1):5720.

18. Riopel, M., Seo, J.B., Bandyopadhyay, G.K., Li, P., Wollam, J., Chung, H., Jung, S.R., Murphy, A., Wilson, M., de Jong, R., et al. (2018). Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function. J Clin Invest 128, 1458-1470.

19. Jin W, Cui B, Li PP, Hua F, Lv XX, Zhou JC, Hu ZW, Zhang XW, 1,25-Dihydroxyvitamin D3 protects obese rats from metabolic syndrome via promoting regulatory T cell-mediated resolution of inflammation. Acta Pharmaceutica Sinica B 2018; 8(2):178-187.

20. Johnson, A. M. F., Hou, S., and Li, P. (2017) Inflammation and insulin resistance: New targets encourage new thinking: Galectin-3 and LTB4 are pro-inflammatory molecules that can be targeted to restore insulin sensitivity. Bioessays 39 (9) PMID: 28752547

21. Ying, W., Riopel, M., Bandyopadhyay, G., Dong, Y., Birmingham, A., Seo, J. B., Ofrecio, J. M., Wollam, J., Hernandez-Carretero, A., Fu, W., Li, P., and Olefsky, J. M. (2017) Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. Cell  doi: 10.1016/j.cell.2017.08.035.

22. Cui B*, Cao XT, Zou WP, Wan YH, Wang N, Wang YH, Li PP, Hua F, Liu YY, Zhang XW, Li K, Lv XX, Huang B#, Hu ZW#. Regulation of immune-related diseases by multiple factors: a meeting report of 2017 International Workshop of the Chinese Academy of Medical Sciences Initiative for Innovative Medicine on Tumor Immunology. Acta Pharmaceutica Sinica B 2017;7(4):532-540.

23. Ying, W., Wollam, J., Ofrecio, J. M., Bandyopadhyay, G., El Ouarrat, D., Lee, Y. S., Oh, D. Y., Li, P., Osborn, O., and Olefsky, J. M. (2017) Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. J Clin Invest 127, 1019-1030 PMID: 28192375

24. Qian, H., Chen, Y., Nian, Z., Su, L., Yu, H., Chen, F. J., Zhang, X., Xu, W., Zhou, L., Liu, J., Yu, J., Yu, L., Gao, Y., Zhang, H., Zhang, H., Zhao, S., Yu, L., Xiao, R. P., Bao, Y., Hou, S., Li, P., Li, J., Deng, H., Jia, W., and Li, P. (2017) HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage. J Clin Invest 127, 1353-1369 PMID:28287402

25. Li PP*, Liu SN, Lu M, Bandyopadhyay G, Oh D, Imamura T, Johnson, A.M.F., Sears D, Shen ZF, Cui B, Kong LJ, Hou SC, Liang X, Iovino S, Watkins SM, Ying W, Osborn O, Wollam J, Brenner M, Olefsky JM*. Hematopoietic-derived Galectin-3 Causes Cellular and Systemic Insulin Resistance. Cell 2016. 167(4):973-984.e12 (Lead Contact, * co-corresponding author) PMID: 27814523

26. Baeza-Raja, B., Sachs, B. D.,  Li, P., Christian, F., Vagena, E., Davalos, D., Le Moan, N., Ryu, J. K., Sikorski, S. L., Chan, J. P., Scadeng, M., Taylor, S. S., Houslay, M. D., Baillie, G. S., Saltiel, A. R., Olefsky, J. M., and Akassoglou, K. (2016) p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.  Cell reports  14, 255-268. PMID: 26748707

27. Lackey DE, Lazaro RG, Li P, Johnson A, Hernandez-Carretero A, Weber N, Vorobyova I, Tsukomoto H, and Osborn O. The role of dietary fat in obesity-induced insulin resistance. Am J Physiol Endocrinol Metab. 2016;311(6):E989-E97. PMID: 27802965

28. Li P*,  Oh DY, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, Johnson A,Chung H, Mayoral R, Maris M, Ofrecio JM, Taguchi S, Lu M, Olefsky JM*. LTB4promotes insulin resistance in obese mice by acting on macrophages, hepatocytesand myocytes. Nat Med. 2015; 21(3): 239-47. (* co-corresponding author) PMID: 25706874.

29. Bernardo, B., Lu, M., Bandyopadhyay, G.,  Li, P., Zhou, Y., Huang, J., Levin, N., Tomas, E. M., Calle, R. A., Erion, D. M., Rolph, T. P., Brenner, M., and Talukdar, S. (2015) FGF21 does not require interscapular brown adipose tissue and improves liver metabolic profile in animal models of obesity and insulin-resistance.  Scientific reports  5, 11382. PMID: 26153793

30. Mayoral, R., Osborn, O., McNelis, J., Johnson, A. M., Oh da, Y., Izquierdo, C. L., Chung, H.,  Li, P., Traves, P. G., Bandyopadhyay, G., Pessentheiner, A. R., Ofrecio, J. M., Cook, J. R., Qiang, L., Accili, D., and Olefsky, J. M. (2015) Adipocyte SIRT1 knockout promotes PPARgamma activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Molecular metabolism 4, 378-391. PMID: 25973386

31. Lu, M.,  Li, P., Bandyopadhyay, G., Lagakos, W., Dewolf, W. E., Jr., Alford, T., Chicarelli, M. J., Williams, L., Anderson, D. A., Baer, B. R., McVean, M., Conn, M., Veniant, M. M., and Coward, P. (2014) Characterization of a novel glucokinase activator in rat and mouse models.  PloS one  9, e88431. PMID: 24533087

32. Li, P. *,  Spann, N.*, Kaikkonen, M., Lu, M., Oh, D., Fox, J., Bandyopadhyay, G., Talukdar, S., Xu, J., Lagakos, W., Patsouris, D., Armando, A., Quehenberger, O., Dennis, E., Watkins, S., Auwerx, J., Glass, C., Olefsky, J.  NCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids.  Cell 2013; 155, 200-214. (* co-first author) PMID: 24074869

33. Lu, M., Sarruf, D.A.,  Li, P.,  Osborn, O., Sanchez-Alavez, M., Talukdar, S., Chen, A., Bandyopadhyay, G., Xu, J., Morinaga, H., et al. (2013). Neuronal sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. The Journal of biological chemistry 288, 10722-10735. PMID: 23457303

34. Reilly, S. M., Chiang, S. H., Decker, S. J., Chang, L., Uhm, M., Larsen, M. J., Rubin, J. R., Mowers, J., White, N. M., Hochberg, I., Downes, M., Yu, R. T., Liddle, C., Evans, R. M., Oh, D.,  Li, P.,  Olefsky, J. M., and Saltiel, A. R. (2013) An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nature medicine 19, 313-321. PMID: 23396211

35. Baeza-Raja B,  Li PP*,  D. Sachs B, Davalos D, Eirini Vagena, Schachtrup C, Loucks FA, Sikorski S, Helmrick M, Le Moan N, Bridges D, Tsigelny I, Baron LJ, Wynshaw-Boris. Anthony , Miriam Scadeng, Saltiel AR, Olefsky JM, Akassoglou K: p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A 2012; 109(15):5838-43 (* co-first author) PMID: 22460790

36. Jonker, J.W., Suh, J.M., Atkins, A.R., Ahmadian, M.,  Li, P.,  Whyte, J., He, M., Juguilon, H., Yin, Y.Q., Phillips, C.T., et al. (2012). A PPARgamma-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature 485, 391-394. PMID: 22522926

37. Osborn, O., Oh, D.Y., McNelis, J., Sanchez-Alavez, M., Talukdar, S., Lu, M.,  Li, P.,  Thiede, L., Morinaga, H., Kim, J.J., et al. (2012). G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice. J Clin Invest 122, 2444-2453. PMID: 22653059

38. Talukdar, S., Oh da, Y., Bandyopadhyay, G., Li, D., Xu, J., McNelis, J., Lu, M.,  Li, P.,  Yan, Q., Zhu, Y., et al. (2012). Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase. Nat Med 18, 1407-1412.  PMID: 22863787

39. Xu, J., Morinaga, H., Oh, D.,  Li, P.,  Chen, A., Talukdar, S., Lazarowski, E., Olefsky, J.M., and Kim, J.J. (2012). GPR105 ablation prevents inflammation and improves insulin sensitivity in mice with diet-induced obesity. J Immunol 189, 1992-1999. PMID: 22778393

40. Nguyen, M. T., Chen, A., Lu, W. J., Fan, W.,  Li, P. P., Oh, D. Y., and Patsouris, D. (2012) Regulation of chemokine and chemokine receptor expression by PPARgamma in adipocytes and macrophages. PloS one 7, e34976 . PMID: 22529965

41. He, B. K., Ning, Z. Q., Li, Z. B., Shan, S., Pan, D. S., Ko, B. C.,  Li, P. P.,  Shen, Z. F., Dou, G. F., Zhang, B. L., Lu, X. P., and Gao, Y. (2012) In Vitro and In Vivo Characterizations of Chiglitazar, a Newly Identified PPAR Pan-Agonist. PPAR research 2012, 546-548.  PMID: 23150725

42. Li PP*,  Fan W, Xu J, Lu M, Yamamoto H, Auwerx J, Sears DD, Talukdar S, Oh D, Chen A, Bandyopadhyay G, Scadeng M, Ofrecio JM, Nalbandian S, Olefsky JM: Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity.     Cell   2011;147:815-826. PMID: 22078880

43. Lee YS,  Li PP*,  Huh JY, Hwang IJ, Lu M, Kim JI, Ham M, Talukdar S, Chen A, Lu WJ, Bandyopadhyay GK, Schwendener R, Olefsky J, Kim JB: Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance. Diabetes 2011;60:2474-2483. (* co-first author). PMID: 21911747

44. Lu M, Sarruf DA, Talukdar S, Sharma S,  Li PP,  Bandyopadhyay G, Nalbandian S, Fan W, Gayen JR, Mahata SK, Webster NJ, Schwartz MW, Olefsky JM: Brain PPAR-gamma promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nat Med 2011;17:618-622. PMID: 21532596

45. Li PP*,  Lu M, Nguyen MT, Bae EJ, Chapman J, Feng D, Hawkins M, Pessin JE, Sears DD, Nguyen AK, Amidi A, Watkins SM, Nguyen U, Olefsky JM: Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice. J Biol Chem 2010;285:15333-15345. PMID: 20308074

46. Lu M,  Li PP*,  Pferdekamper J, Fan W, Saberi M, Schenk S, Olefsky JM: Inducible nitric oxide synthase deficiency in myeloid cells does not prevent diet-induced insulin resistance. Mol Endocrinol 2010;24:1413-1422. (* co-first author). PMID: 20444886

47. Lu M, Patsouris D, Li PP,  Flores-Riveros J, Frincke JM, Watkins S, Schenk S, Olefsky JM: A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. Am J Physiol Endocrinol Metab 2010;298:E1036-1048. PMID: 20159859

48. Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W,  Li PP,  Lu WJ, Watkins SM, Olefsky JM: GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell 2010;142:687-698. PMID: 20813258

49. Kim JJ,  Li PP,  Huntley J, Chang JP, Arden KC, Olefsky JM: FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue. Diabetes 2009;58:1275-1282. PMID: 19289458

50. Saberi M, Bjelica D, Schenk S, Imamura T, Bandyopadhyay G,  Li PP,  Jadhar V, Vargeese C, Wang W, Bowman K, Zhang Y, Polisky B, Olefsky JM: Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes. Am J Physiol Endocrinol Metab 2009;297:E1137-1146. PMID: 19706791

51. Yeh TY, Beiswenger KK,  Li PP,  Bolin KE, Lee RM, Tsao TS, Murphy AN, Hevener AL, Chi NW: Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase-deficient mice. Diabetes 2009;58:2476-2485. PMID: 19651815

52. Patsouris D, Neels JG, Fan W,  Li PP,  Nguyen MT, Olefsky JM: Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment. J Biol Chem 2009;284:31223-31235. PMID: 19740750

53. Patsouris D,  Li PP*,  Thapar D, Chapman J, Olefsky JM, Neels JG: Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 2008;8:301-309. (* co-first author). PMID: 18840360

54. Nofsinger RR,  Li PP,  Hong SH, Jonker JW, Barish GD, Ying H, Cheng SY, Leblanc M, Xu W, Pei L, Kang YJ, Nelson M, Downes M, Yu RT, Olefsky JM, Lee CH, Evans RM: SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc Natl Acad Sci U S A 2008;105:20021-20026. PMID: 19066220

55. Wang ZJ, Liu Q,  Li PP,  Zou CH, Shen ZF: Effect of GCP-02, a PPARalpha/gamma dual activator, on glucose and lipid metabolism in insulin-resistant mice. Eur J Pharmacol 2008;580:277-283. PMID: 18048028

56. Li PP*,  Shan S, Chen YT, Ning ZQ, Sun SJ, Liu Q, Lu XP, Xie MZ, Shen ZF: The PPARalpha/gamma dual agonist chiglitazar improves insulin resistance and dyslipidemia in MSG obese rats. Br J Pharmacol 2006;148:610-618. PMID: 16751799

57. Deng T, Shan S,  Li PP,  Shen ZF, Lu XP, Cheng J, Ning ZQ: Peroxisome proliferator-activated receptor-gamma transcriptionally up-regulates hormone-sensitive lipase via the involvement of specificity protein-1. Endocrinology 2006;147:875-884. PMID: 16269451

58. Cai ZF, Liu Q,  Li PP,  Guo ZR, Shen ZF: Synthesis and anti-diabetic activity of (RS)-2-ethoxy-3-{4-[2-(4-trifluoro-methanesulfonyloxy-phenyl)-ethoxy]-phenyl}-pro pionic acid. Acta Pharmacol Sin 2006;27:597-602. PMID: 16626515

59. Cai Z, Feng J, Guo Y,  Li PP,  Shen Z, Chu F, Guo Z: Synthesis and evaluation of azaindole-alpha-alkyloxyphenylpropionic acid analogues as PPARalpha/gamma agonists. Bioorg Med Chem 2006;14:866-874. PMID: 16249089

 

 

专著

1.     庾石山,陈晓光,石建功,刘云宝,胡卓伟,尹大力,刘玉玲,胡友财,李平平. 精准医学出版工程·精准医学药物研发系列-天然药物精准研发

 

 

 

 

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