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侯琦

时间:2021/3/19 来源: 阅读:23111次


侯琦

 

侯琦,女,研究员,博士生导师。现就职于中国医学科学院药物研究所药理室,任抗炎免疫课题组组长。主要从事抗炎免疫药理学研究。科技部、卫生部、教育部重大科研项目以及国家自然科学基金项目的评审专家。近年来承担或参与国家自然科学基金面上项目等众多项科研项目,在ApoptosisJBCJLRJMC等期刊上发表研究论文30多篇,申请专利20多项,并获得科技奖励2项。

联系电话:010-63165191;邮箱:houq@imm.ac.cn

 

教育背景

       2001/02 – 2003/05,南卡罗莱那医科大学(MUSCUSA),博士后

 1997/9-2000/6, 中国医学科学院药物研究所,博士

 1989/09 - 1991/06,山东大学医学院,硕士

 1982/09-1987/06   滨州医学院,学士

 

工作经历

2007/03 - 至今,中国医学科学院药物研究所,研究员。

 2003/5-2007/3MUSCUSA,助理教授

1987/9-1997/6 潍坊医学院,天然药物与药理学研究室,副教授

 

专业研究领域

1.       抗炎免疫药理学及其相关新药研究

2.       哮喘、COPD炎症调控新靶点新机制研究

3.       风湿性、类风湿性以及骨关节炎药物筛选与发现研究

4.       再生障碍性贫血免疫病理机制及其调控药物研究

5.       基于靶标抗原-免疫磁珠的中药致敏原筛选与评价

 

近年内发表的主要研究论文

1 Pei Ma#, Shuyi Li#, Hui Yang, Jiqiao Yuan, Ziqian Zhang, Xuyu Li, Nan Fang, Mingbao Lin* and Qi Hou*. Comparative RNA‐Seq transcriptome analysis on pulmonary inflammation in a mouse model of asthma-COPD overlap syndrome. Frontiers in Cell and Developmental Biology. 2021doi: 10.3389/fcell.2021.628957.

2 Yasi Ding#, Weibin Tang#, Fei Pei#, Lixia Fu, Pei Ma, Jinye Bai, Mingbao Lin*, Yunbao Liu*, Qi Hou*. Brusatol Derivative - 34 Attenuates Allergic Airway Inflammation via Inhibition of the Syk Pathway. Frontiers in Pharmacology. 2021, doi: 10.3389/fphar.2021.587417.

3 Hui Yang,Wei Sun, Pei Ma,Chunsuo Yao,Yannan Fan,Shuyi Li,Jiqiao Yuan,Xuyu Li, Mingbao Lin*,Qi Hou*. Multiple Components Rapidly Screened from Perilla Leaves Attenuate Asthma Airway Inflammation by Synergistic Targeting on Syk. Journal of Inflammation Research. 2020:13 897–911.

4 Pei Ma, Lifeng Yue, Hui Yang, Yannan Fan, Jinye Bai, Shuyi Li, Jiqiao Yuan, Ziqian Zhang, Chunsuo Yao, Mingbao Lin*, Qi Hou*. hondroprotective and anti-inflammatory effects of amurensin H by regulating TLR4/Syk/NF-κB signals. J Cell Mol Med. 2020;24:1958–1968

5 Yannan Fan, Ziqian Zhang, Chunsuo Yao, Jinye Bai, Hui Yang, Pei Ma, Yiyao Fan, Shuyi Li, Jiqiao Yuan, Mingbao Lin* and Qi Hou*. Amurensin H, a derivative from resveratrol, ameliorates lipopolysaccharide / cigarette smoke‐induced airway inflammation by blocking the Syk/NF-κB pathway. Frontiers in Pharmacology. 2019, 10: 1157.

6 Hui Yang#, Jing Guan#, Pei Ma, Yannan Fan, Jinye Bai, Shuyi Li, Jiqiao Yuan,Yecheng Jin, Mingbao Lin#*, Jianmin Zhang*, and Qi Hou*. Beneficial Effects of Qingzixiaoban Granule on Henoch–Sch¨onlein Purpura Nephritis Mice through Inhibiting Immune Complex Deposition and Th2 Immunodeviation. ECAM. 2019: 3050248.

7 Yuanyuan Zhuang#, Jiabao Liu#, Pei Ma#, Jinye Bai, Yasi Ding, Hui Yang, Yannan Fan, Mingbao Lin*, Shuai Li*, Qi Hou*. Tamarixinin A alleviates joint destruction of rheumatoid arthritis by blockade of MAPK and NF-κB activation. Frontiers in Pharmacology. 2017, 8: 538.

8 Lingling Xuan, Rentao Jiang, Zhiyuan Wu, Honggan Yi, Chunsuo Yao, Qi Hou*, Chunfeng Qu*. Vam3, a Compound Derived from Vitis amurensis Rupr., Attenuated Colitis-Related Tumorigenesis by Inhibiting NF-kappa B Signaling Pathway , Frontiers in Pharmacology, 2016.9.13, 7.

9 Yunxiao Li, Ganggang Y u, Shaopeng Yuan, Chunting Tan, Jianlin Xie, Yasi Ding, Puqiao Lian, Lixia Fu, Qi Hou*, Bo Xu*, Haoyan Wang*.  14,15- Epoxyeicosatrienoic acid suppresses cigarette smoke condensate-induced inflammation in lung epithelial cells by inhibiting autophagy, AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2016.11.1, 311(5): L970~L980.

10 Junling Zhang, Xiaolei Xue, Xiaodan Han, Chunsuo Yao, Lu Lu, Deguan Li, Qi Hou*, Weimin Miao, Aimin Meng*, Saijun Fan*. Vam3 ameliorates total body irradiation-induced hematopoietic system injury partly by regulating the expression of Nrf2-targeted genes , FREE RADICAL BIOLOGY AND MEDICINE, 2016.12, 101: 455~464.

 

 

 

 

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