中文版English

Home | Add to Favorites | Contact Us

Research Achievement

Home >> Research Achievements >> Publication

Lysidicins F-H, three new phloroglucinols from Lysidice rhodostegia

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, PR China.
 
Abstract
Three new phloroglucinols, named lysidicins F-H (1-3), were isolated from the roots of Lysidice rhodostegia. These compounds have a unprecedented benzyl benzo[b]furo[3,2-d]furan skeleton, and lysidicin F (1) is the first example of natural product with trans-fused furan rings. Their structures were established on the basis of extensive spectroscopic analysis, and the absolute configurations of them were determined by computational methods. A possible biosynthetic pathway for 1-3 was also postulated. 

Organic Letters,2010,12(10):2390-2393.

 

【Back】