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戴均贵

时间:2018-4-20 来源: 阅读:22759次


戴均贵

 

戴均贵  湖北浠水人,1969年出生,博士,研究员,博士生导师,协和学者特聘教授,入选2017年“国家百千万人才工程”并被授予“有突出贡献中青年专家”称号。1991年、1996年获华中师范大学生物学学士、植物学专业硕士学位,1999年获中国协和医科大学生药学博士学位。1999-2001年、2001-2003年在北京大学医学部、日本新泻大学化学系进行博士后(JSPS)研究工作。200310月至今在中国医学科学院药物研究所天然药物活性物质与功能国家重点实验室、卫健委天然药物生物合成重点实验室工作,研究方向为药用天然产物生物合成与生物催化。已在国际学术期刊包括Nature Chemical Biology, Angewandte Chemie International Edition, Organic Letters, Advanced Synthesis & Catalysis, Chemistry-A European Journal, The Journal of Biological Chemistry, Journal of Natural Products, ChemBioChem, Tetrahedron, Phytochemistry等及国内学术期刊《药学学报》等上发表学术论文170余篇;申请发明专利9项,授权3项,参加编写专著6.

联系方式:010-63165195       邮箱:  jgdai@imm.ac.cn  

 

主要研究方向

1)天然药物生物合成  开展药用植物与微生物活性天然产物生物合成研究,揭示其生物合成途径,尤其对其生物合成途径中关键酶及其反应机制进行阐释,人工构建生物合成途径并高效生产目标活性天然产物及非天然天然产物,解决药源不足问题及发现药物先导分子。

2)天然药物生物催化  针对复杂结构活性天然产物结构优化中重要而化学法较难实现的选择性糖苷化、异戊烯基化、羟基化等反应,发掘新颖生物催化酶;采用结构生物学并结合定点突变等策略揭示催化机理及其杂泛性与选择性的结构基础,结构导向下对其进行理性设计,实现活性天然产物的可设计性、高效结构优化。

3)特殊生境微生物中新颖结构活性天然产物的发现  从植物内生真菌、海洋微生物等中发现新颖结构活性天然产物,为新药研制提供具自主知识产权的先导化合物,亦为新颖结构活性天然产物的生物合成研究及新颖酶的发现及其酶学机制的阐释奠定基础。

 

代表性论文*通讯作者):

1. Ridao Chen, Bingquan Gao, Xiao Liu, Feiying Ruan, Yong Zhang, Jizhong Lou, Keping Feng, Carsten Wunsch, Shu-Ming Li, Jungui Dai*, Fei Sun*. Molecular insights into the enzyme promiscuity of an aromatic prenyltransferase. Nature Chemical Biology, 2017, 13, 226-234.

2. Dawei Chen, Ridao Chen, Ruishan Wang, Jianhua Li, Kebo Xie, Chuancai Bian, Lili Sun, Xiaolin Zhang, Jimei Liu, Lin Yang, Fei Ye, Xiaoming Yu, and Jungui Dai*. Probing the catalytic promiscuity of a regio- and stereo-specific C-glycosyltransferase from Mangifera indica. Angewandte Chemie International Edition, 2015, 54, 12678-12682.

3. Dawei Chen, Ridao Chen, Kebo Xie, Tian Yue, Xiaolin Zhang, Fei Ye, and Jungui Dai*. Biocatalytic C-glucosylation of coumarins using an engineered C-glycosyltransferase. Organic Letters, 2018, 20, 1634-1637.

4. Min Zhang, Jimei Liu, Ridao Chen, Jinlian Zhao, Kebo Xie, Dawei Chen, Keping Feng, and Jungui Dai*. Two furanharzianones with 4/7/5/6/5 ring system from microbial transformation of harzianone. Organic Letters, 2017, 19, 1168-1171.

5. Dewu Zhang, Xiaoyu Tao, Ridao Chen, Jimei Liu, Li Li, Xiaomei Fang, Liyan Yu, and Jungui Dai*. Pericoannosin A, a polyketide synthase–nonribosomal peptide synthetase hybrid metabolite with new carbon skeleton from the endophytic fungus Periconia sp. Organic Letters, 2015, 17, 4304-4307.

6. Kebo Xie, Ridao Chen, Jianhua Li, Ruishan Wang, Dawei Chen, Xiaoxiang Dou, and Jungui Dai*. Exploring the catalytic promiscuity of a new glycosyltransferase from Carthamus tinctorius. Organic Letters, 2014, 16, 4874-4877.

7. Dewu Zhang, Hanlin Ge, Jian-hua Zou, Xiaoyu Tao, Ridao Chen, and Jungui Dai*. Periconianone A, a new 6/6/6 carbocyclic sesquiterpenoid from endophytic fungus Periconia sp. with neural anti-inflammatory activity. Organic Letters, 2014, 16, 1410-1413.

8. Dewu Zhang, Hanlin Ge, Dan Xie, Ridao Chen, Jian-hua Zou, Xiaoyu Tao, and Jungui Dai*. Periconiasins A–C, new cytotoxic cytochalasans with an unprecedented 9/6/5 tricyclic ring system from endophytic fungus Periconia sp. Organic Letters, 2013, 15, 1674−1677.

9. Xiao Liu, Dan Xie, Ridao Chen, Mei Mei, Jianhua Zou, Xiaoguang Chen and Jungui Dai*. A Furantaxane with an unusual 6/8/6/5 ring system and potent tumor MDR reversal activity obtained via microbial transformation. Organic Letters, 2012, 14, 41064109.

10. Kebo Xie, Ridao Chen, Dawei Chen, Jianhua Li, Ruishan Wang, Lin Yang and Jungui Dai*. Enzymatic N-glycosylation of diverse arylamine aglycons by a promiscuous glycosyltransferase from Carthamus tinctorius. Advanced Synthesis & Catalysis, 2017, 359, 603-608.

11Ridao Chen, Xiao Liu, Jianhua Zou, Yunze Yin, Bin Ou, Jianhua Li, Ruishan Wang, Dan Xie, Peicheng Zhang, Jungui Dai*. Regio- and stereospecific prenylation of flavonoids by Sophora flavescens prenyltransferase. Advanced Synthesis & Catalysis, 2013, 355, 18171828.

12. Dawei Chen, Lili Sun, Ridao Chen, Kebo Xie, Lin Yang, and Jungui Dai*. Enzymatic synthesis of acylphloroglucinol 3-C-glucosides from 2-O-glucosides using a C-glycosyltransferase from Mangifera indica. Chemistry-A European Journal, 2016, 22, 5873-5877.

13. Ruishan Wang, Ridao Chen, Jianhua Li, Xiao Liu, Kebo Xie, Dawei Chen, Yunze Yin, Xiaoyu Tao, Dan Xie, Jianhua Zou, Lin Yang, and Jungui Dai*. Molecular characterization and phylogenetic analysis of two novel regio-specific flavonoid prenyltransferases from Morus alba and Cudrania tricuspidata. The Journal of Biological Chemistry, 2014, 289, 35815-35825.

14. Kebo Xie, Xiaoxiang Dou, Ridao Chen, Dawei Chen, Cheng Fang, Zhiyan Xiao, Jungui Dai*. Two novel fungal phenolic UDP glycosyltransferases from Absidia coerulea and Rhizopus japonicus. Applied Environmental Microorganism, 2017, 83, e03103-16.

15. Jinlian Zhao, Jiamin Feng, Zhen Tan, Jimei Liu, Jianyuan Zhao, Ridao Chen, Kebo Xie, Dewu Zhang, Yan Li, Liyan Yu, Xiaoguang Chen, and Jungui Dai*. Stachybotrysins A-G, new phenylspirodrimane derivatives from the fungus Stachybotrys chartarum. Journal of Natural Products, 2017, 1819−1826.

16. Dewu Zhang, Jiamei Guo, Min Zhang, Xiao Liu, Mingyu Ba, Xiaoyu Tao, Liyan Yu, Ying Guo,* and Jungui Dai*. Oxazole-containing diterpenoids from cell cultures of Salvia miltiorrhiza and their anti-HIV-1 activities. Journal of Natural Products, 2017, 80, 3241-3246.

17. Jimei Liu, Dewu Zhang, Min Zhang, Jinlian Zhao, Ridao Chen, Nan Wang, Dan Zhang, and Jungui Dai*. Eremophilane sesquiterpenes from an endophytic fungus Periconia species. Journal of Natural Products, 2016, 79, 2229-2235.

18. Ruishan Wang, Ridao Chen, Jianhua Li, Xiao Liu, Kebo Xie, Dawei Chen, Ying Peng,* and Jungui Dai*. Regiospecific prenylation of hydroxyxanthones by a plant flavonoid prenyltransferase. Journal of Natural Products, 2016, 79, 2143-2147.

19. Keping Feng, Ridao Chen, Kebo Xie, Dawei Chen, Baolin Guo, Xiao Liu, Jimei Liu, Min Zhang, and Jungui Dai. A regiospecific rhamnosyltransferase from Epimedium pseudowushanense catalyzes the 3-O-rhamnosylation of prenylflavonols. Organic & Biomolecular Chemistry, 2018, 16, 452-458.

20. Jianhua Li, Ridao Chen, Ruishan Wang, Xiao Liu, Dan Xie, Jianhua Zou, and Jungui Dai*. GuA6DT, a Regiospecific prenyltransferase from Glycyrrhiza uralensis, catalyzes the 6-prenylation of flavones. ChemBioChem, 2014, 15, 1673-1681.

 

 

 

 

 

 

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